Cellular quality control systems sense and mediate homeostatic responses to prevent the
buildup of aberrant macromolecules, which arise from errors during biosynthesis, damage …

Reactive oxygen species (ROS) play a crucial part in the process of cell death, including
apoptosis, autophagy, and ferroptosis. ROS involves in the oxidation of lipids and generate …

Phospholipids containing a single polyunsaturated fatty acyl tail (PL-PUFA 1 s) are
considered the driving force behind ferroptosis, whereas phospholipids with diacyl-PUFA …

Ferroptosis, a regulated cell death pathway driven by accumulation of phospholipid
peroxides, has been challenging to identify in physiological conditions owing to the lack of a …

Oxidative stress has been shown to induce cell death in a wide range of human diseases
including cardiac ischemia/reperfusion injury, drug induced cardiotoxicity, and heart failure …

Precise manipulation of cancer cell death by harnessing reactive oxygen species (ROS) is a
promising strategy to defeat malignant tumors. However, it is quite difficult to produce active …

A stable mitochondrial pool is crucial for healthy cell function and survival. Altered redox
biology can adversely affect mitochondria through induction of a variety of cell death and …

Iron is an important metal element involved in the regulation of male reproductive functions
and has dual effects on testicular tissue. A moderate iron content is necessary to maintain …

Ferroptosis induced by erastin (an inhibitor of cystine transport) and butionine sulfoximine
(an inhibitor of glutathione biosynthesis) was prevented by the mitochondria-targeted …

Sorafenib is an important first-line treatment option for liver cancer due to its well-
characterized safety profile. While novel first-line drugs may have better efficacy than …