Adult skeletal muscle fibers are among the few cell types that are truly multinucleated.
Recently, evidence has accumulated supporting a role for the modulation of myonuclear …

Until recently, cells were thought to be integral and discrete components of tissues, and their
state was determined by cell differentiation. However, under some conditions, stem cells or …

Skeletal muscle in vertebrates is derived from somites, epithelial structures of the paraxial
mesoderm, yet many unrelated reports describe the occasional appearance of myogenic …

Injection of the myotoxin notexin, was found to induce regeneration in muscles that had
been subjected to 18 Gy of radiation. This finding was unexpected as irradiation doses of …

This book will be a resource for the experienced tissue engineer, a starting point for the
student, and a guidebook for the next generation of tissue engineers. Contained in one …

The fusion of muscle precursor cells is a required event for proper skeletal muscle
development and regeneration. Numerous proteins have been implicated to function in …

In postnatal muscle, skeletal muscle precursors (myoblasts) can be derived from satellite
cells (reserve cells located on the surface of mature myofibers) or from cells lying beyond the …

Duchenne muscular dystrophy (DMD) is a severe progressive muscle-wasting disorder
caused by mutations in the dystrophin gene. Studies have shown that bone marrow cells …

Ex vivo gene therapy of primary myopathies, based on autologous transplantation of
genetically modified myogenic cells, is seriously limited by the number of primary myogenic …

We have tested the feasibility of muscle-based gene therapy and tissue engineering for
urological dysfunction using highly purified muscle-derived cells (MDC) that display stem …