The proteostasis network and its decline in ageing
Ageing is a major risk factor for the development of many diseases, prominently including
neurodegenerative disorders such as Alzheimer disease and Parkinson disease. A hallmark …
neurodegenerative disorders such as Alzheimer disease and Parkinson disease. A hallmark …
A practical review of proteasome pharmacology
TA Thibaudeau, DM Smith, Q Ma - Pharmacological reviews, 2019 - Elsevier
The ubiquitin proteasome system (UPS) degrades individual proteins in a highly regulated
fashion and is responsible for the degradation of misfolded, damaged, or unneeded cellular …
fashion and is responsible for the degradation of misfolded, damaged, or unneeded cellular …
The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation
Cells use ubiquitin to mark proteins for proteasomal degradation. Although the proteasome
also eliminates proteins that are not ubiquitinated, how this occurs mechanistically is …
also eliminates proteins that are not ubiquitinated, how this occurs mechanistically is …
[HTML][HTML] Remaining mysteries of molecular biology: the role of polyamines in the cell
The polyamines (PAs) spermidine, spermine, putrescine and cadaverine are an essential
class of metabolites found throughout all kingdoms of life. In this comprehensive review, we …
class of metabolites found throughout all kingdoms of life. In this comprehensive review, we …
[HTML][HTML] Proteostasis, oxidative stress and aging
I Korovila, M Hugo, JP Castro, D Weber, A Höhn… - Redox biology, 2017 - Elsevier
The production of reactive species is an inevitable by-product of metabolism and thus, life
itself. Since reactive species are able to damage cellular structures, especially proteins, as …
itself. Since reactive species are able to damage cellular structures, especially proteins, as …
Proteasome inhibitor drugs
LD Fricker - Annual review of pharmacology and toxicology, 2020 - annualreviews.org
Proteasomes are large, multicatalytic protein complexes that cleave cellular proteins into
peptides. There are many distinct forms of proteasomes that differ in catalytically active …
peptides. There are many distinct forms of proteasomes that differ in catalytically active …
Phosphorylation meets ubiquitination: the control of NF-κB activity
M Karin, Y Ben-Neriah - Annual review of immunology, 2000 - annualreviews.org
NF-κB (nuclear factor-κB) is a collective name for inducible dimeric transcription factors
composed of members of the Rel family of DNA-binding proteins that recognize a common …
composed of members of the Rel family of DNA-binding proteins that recognize a common …
Recognition and processing of ubiquitin-protein conjugates by the proteasome
D Finley - Annual review of biochemistry, 2009 - annualreviews.org
The proteasome is an intricate molecular machine, which serves to degrade proteins
following their conjugation to ubiquitin. Substrates dock onto the proteasome at its 19 …
following their conjugation to ubiquitin. Substrates dock onto the proteasome at its 19 …
The proteasome: overview of structure and functions
K Tanaka - Proceedings of the Japan Academy, Series B, 2009 - jstage.jst.go.jp
The proteasome is a highly sophisticated protease complex designed to carry out selective,
efficient and processive hydrolysis of client proteins. It is known to collaborate with ubiquitin …
efficient and processive hydrolysis of client proteins. It is known to collaborate with ubiquitin …
Modulation of cellular function by polyamines
K Igarashi, K Kashiwagi - The international journal of biochemistry & cell …, 2010 - Elsevier
Polyamines (putrescine, spermidine and spermine) are essential for normal cell growth. The
polyamine levels in cells are regulated by biosynthesis, degradation, and transport …
polyamine levels in cells are regulated by biosynthesis, degradation, and transport …