Epilepsy in neurodegenerative diseases: related drugs and molecular pathways

A Cano, E Fonseca, M Ettcheto, E Sánchez-López… - Pharmaceuticals, 2021 - mdpi.com
Epilepsy is a chronic disease of the central nervous system characterized by an electrical
imbalance in neurons. It is the second most prevalent neurological disease, with 50 million …

Epileptic seizures in Alzheimer disease: a review

A Horváth, A Szűcs, G Barcs, JL Noebels… - Alzheimer Disease & …, 2016 - journals.lww.com
Alzheimer disease (AD) is the most frequent cause of major neurocognitive disorders with a
huge economical and medical burden. Several studies pointed out that AD is associated …

Biological signatures of Alzheimer's disease

P Sharma, A Sharma, F Fayaz… - Current Topics in …, 2020 - ingentaconnect.com
Alzheimer's disease (AD) is the most prevalent and severe neurodegenerative disease
affecting more than 0.024 billion people globally, more common in women as compared to …

Epilepsy and Alzheimer's Disease: Potential mechanisms for an association

FS Giorgi, LF Saccaro, CL Busceti, F Biagioni… - Brain Research …, 2020 - Elsevier
Alzheimer's Disease (AD) and epilepsy are common neurological diseases. The prevalence
of epilepsy in AD patients is higher than in healthy subjects, but identifying the reasons for …

Endoplasmic reticulum stress and its role in various neurodegenerative diseases

R Singh, N Kaur, V Choubey, N Dhingra, T Kaur - Brain Research, 2024 - Elsevier
The Endoplasmic reticulum (ER), a critical cellular organelle, maintains cellular homeostasis
by regulating calcium levels and orchestrating essential functions such as protein synthesis …

[HTML][HTML] The epidemiological scale of Alzheimer's disease

G Cornutiu - Journal of clinical medicine research, 2015 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) has increased from a few cases in a country at the beginning of
the 20th century to an incidence of recording a case every 7 seconds in the world. From a …

[HTML][HTML] Molecular biomarkers of neuronal injury in epilepsy shared with neurodegenerative diseases

D Negi, S Granak, S Shorter, VB O'Leary, I Rektor… - …, 2023 - Elsevier
In neurodegenerative diseases, changes in neuronal proteins in the cerebrospinal fluid and
blood are viewed as potential biomarkers of the primary pathology in the central nervous …

Beta-amyloid precursor protein (βAPP) processing in Alzheimer's disease (AD) and age-related macular degeneration (AMD)

Y Zhao, S Bhattacharjee, BM Jones, JM Hill… - Molecular …, 2015 - Springer
Amyloid is a generic term for insoluble, often intensely hydrophobic, fibrous protein
aggregates that arise from inappropriately folded versions of naturally-occurring …

Epileptic mechanisms shared by Alzheimer's disease: Viewed via the unique lens of genetic epilepsy

JQ Kang - International Journal of Molecular Sciences, 2021 - mdpi.com
Our recent work on genetic epilepsy (GE) has identified common mechanisms between GE
and neurodegenerative diseases including Alzheimer's disease (AD). Although both …

Neuroinflammation: A common pathway in Alzheimer's disease and epilepsy

Y Liew, T Retinasamy, A Arulsamy, I Ali… - Journal of …, 2023 - content.iospress.com
Background: Neuroinflammation is an innate immunological response of the central nervous
system that may be induced by a brain insult and chronic neurodegenerative conditions …