Fundamental biological features of spaceflight: advancing the field to enable deep-space exploration

E Afshinnekoo, RT Scott, MJ MacKay, E Pariset… - Cell, 2020 - cell.com
Research on astronaut health and model organisms have revealed six features of
spaceflight biology that guide our current understanding of fundamental molecular changes …

Microglia in cancer therapy-related cognitive impairment

EM Gibson, M Monje - Trends in neurosciences, 2021 - cell.com
Millions of cancer survivors experience a persistent neurological syndrome that includes
deficits in memory, attention, information processing, and mental health. Cancer therapy …

Central nervous system regeneration is driven by microglia necroptosis and repopulation

AF Lloyd, CL Davies, RK Holloway, Y Labrak… - Nature …, 2019 - nature.com
Failed regeneration of CNS myelin contributes to clinical decline in neuroinflammatory and
neurodegenerative diseases, for which there is an unmet therapeutic need. Here we reveal …

Challenges to the central nervous system during human spaceflight missions to Mars

GR Clément, RD Boyle, KA George… - Journal of …, 2020 - journals.physiology.org
Space travel presents a number of environmental challenges to the central nervous system,
including changes in gravitational acceleration that alter the terrestrial synergies between …

Traumatic brain injury in aged mice induces chronic microglia activation, synapse loss, and complement-dependent memory deficits

K Krukowski, A Chou, X Feng, B Tiret… - International journal of …, 2018 - mdpi.com
Traumatic brain injury (TBI) is of particular concern for the aging community since there is
both increased incidence of TBI and decreased functional recovery in this population. In …

[HTML][HTML] Novel microglia-mediated mechanisms underlying synaptic loss and cognitive impairment after traumatic brain injury

K Krukowski, A Nolan, MK Becker, K Picard… - Brain, behavior, and …, 2021 - Elsevier
Traumatic brain injury (TBI) is one of the leading causes of long-term neurological disability
in the world. Currently, there are no therapeutics for treating the deleterious consequences …

[HTML][HTML] Behavioral effects of space radiation: A comprehensive review of animal studies

F Kiffer, M Boerma, A Allen - Life sciences in space research, 2019 - Elsevier
As NASA prepares for the first manned mission to Mars in the next 20 years, close attention
has been placed on the cognitive welfare of astronauts, who will likely endure extended …

Proton FLASH radiation therapy and immune infiltration: evaluation in an orthotopic glioma rat model

L Iturri, A Bertho, C Lamirault, M Juchaux… - International Journal of …, 2023 - Elsevier
Purpose FLASH radiation therapy (FLASH-RT) is a promising radiation technique that uses
ultrahigh doses of radiation to increase the therapeutic window of the treatment. FLASH-RT …

Central nervous system responses to simulated galactic cosmic rays

E Cekanaviciute, S Rosi, SV Costes - International journal of molecular …, 2018 - mdpi.com
In preparation for lunar and Mars missions it is essential to consider the challenges to
human health that are posed by long-duration deep space habitation via multiple stressors …

Female mice are protected from space radiation-induced maladaptive responses

K Krukowski, K Grue, ES Frias, J Pietrykowski… - Brain, behavior, and …, 2018 - Elsevier
Interplanetary exploration will be humankind's most ambitious expedition and the journey
required to do so, is as intimidating as it is intrepid. One major obstacle for successful deep …