One of the more transformative findings in human genetics was the discovery that the
expansion of unstable nucleotide repeats underlies a group of inherited neurological …

In this review, we first describe the current understanding of glial-mediated vascular function
affecting the role of the blood-brain barrier (BBB) in central nervous system (CNS) disorders …

The mechanisms underlying the selective regional vulnerability to neurodegeneration in
Huntington's disease (HD) have not been fully defined. To explore the role of astrocytes in …

Huntington's disease (HD) is caused by a CAG repeat expansion in the HTT gene, leading
to altered gene expression. However, the mechanisms leading to disrupted RNA processing …

The molecular causes and mechanisms of neurodegenerative diseases remain poorly
understood. A growing number of single-cell studies have implicated various neural, glial …

Huntington's disease (HD) is a neurodegenerative disorder caused by an expanded CAG
repeat mutation in the Huntingtin (HTT) gene. The mutation impacts neuronal protein …

Huntington's disease (HD), a genetic neurodegenerative disorder, primarily affects the
striatum and cortex with progressive loss of medium-sized spiny neurons (MSNs) and …

Abstract Background and Purpose Amyotrophic lateral sclerosis (ALS) is a fatal
neurodegenerative disorder characterized by progressive motor neuron (MN) loss and …

Neurodegenerative disorders are typically characterized by late onset progressive damage
to specific (sub) populations of cells of the nervous system that are essential for mobility …

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by
a mutant huntingtin protein with an abnormal CAG/polyQ expansion in the N-terminus of …