Parkinson's disease is a neurodegenerative disease caused by the death of neurons, ie,
cells critical to the production of dopamine, an important neurotransmitter in the brain. Here …

The dopaminergic system plays important roles in neuromodulation, such as motor control,
motivation, reward, cognitive function, maternal, and reproductive behaviors. Dopamine is a …

Dopamine receptors are widely distributed within the brain where they play critical
modulator roles on motor functions, motivation and drive, as well as cognition. The …

G protein-coupled receptors (GPCRs) are the largest class of receptors in the human
genome and some of the most common drug targets. It is now well established that GPCRs …

Schizophrenia has been primarily associated with dopamine dysfunction, and treatments
have been developed that target the dopamine pathway in the central nervous system …

One of the recently emerging topics in biotechnology is natural receptors including G protein-
coupled receptors, ligand-gated ion channels, enzyme-linked receptors, and intracellular …

G-protein-coupled receptors (GPCRs) have been tractable drug targets for decades with
over one-third of currently marketed drugs targeting GPCRs. Of these, the class A GPCR …

Catecholamine-stimulated β2-adrenergic receptor (β2AR) signaling via the canonical Gs–
adenylyl cyclase–cAMP–PKA pathway regulates numerous physiological functions …

G protein-coupled receptors (GPCRs) are cell surface receptors that respond to a wide
variety of stimuli, from light, odorants, hormones, and neurotransmitters to proteins and …

Neuropsychiatric disorders are multifactorial disorders with diverse aetiological factors.
Identifying treatment targets is challenging because the diseases are resulting from …