Aflatoxin B1: A review on metabolism, toxicity, occurrence in food, occupational exposure, and detoxification methods

BR Rushing, MI Selim - Food and chemical toxicology, 2019 - Elsevier
Aflatoxins are a class of carcinogenic mycotoxins produced by Aspergillus fungi and are
known to contaminate a large portion of the world's food supply. Aflatoxin B1 (AFB1) is the …

Mycotoxins' toxicological mechanisms involving humans, livestock and their associated health concerns: A review

CG Awuchi, EN Ondari, S Nwozo, GA Odongo… - Toxins, 2022 - mdpi.com
Mycotoxins are well established toxic metabolic entities produced when fungi invade
agricultural/farm produce, and this happens especially when the conditions are favourable …

Aflatoxin B1 and M1: Biological properties and their involvement in cancer development

S Marchese, A Polo, A Ariano, S Velotto, S Costantini… - Toxins, 2018 - mdpi.com
Aflatoxins are fungal metabolites found in feeds and foods. When the ruminants eat
feedstuffs containing Aflatoxin B1 (AFB1), this toxin is metabolized and Aflatoxin M1 (AFM1) …

Risk assessment of aflatoxins in food

EFSA Panel on Contaminants in the Food Chain … - EFSA …, 2020 - Wiley Online Library
EFSA was asked to deliver a scientific opinion on the risks to public health related to the
presence of aflatoxins in food. The risk assessment was confined to aflatoxin B1 (AFB 1) …

Risk assessment of ochratoxin A in food

EFSA Panel on Contaminants in the Food Chain … - EFSA …, 2020 - Wiley Online Library
Abstract The European Commission asked EFSA to update their 2006 opinion on ochratoxin
A (OTA) in food. OTA is produced by fungi of the genus Aspergillus and Penicillium and …

Mycotoxin exposure and human cancer risk: A systematic review of epidemiological studies

L Claeys, C Romano, K De Ruyck… - … Reviews in Food …, 2020 - Wiley Online Library
In recent years, there has been an increasing interest in investigating the carcinogenicity of
mycotoxins in humans. This systematic review aims to provide an overview of data linking …

Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction

M Martignoni, GMM Groothuis… - Expert opinion on drug …, 2006 - Taylor & Francis
Animal models are commonly used in the preclinical development of new drugs to predict
the metabolic behaviour of new compounds in humans. It is, however, important to realise …

Polymorphism of human cytochrome P450 enzymes and its clinical impact

SF Zhou, JP Liu, B Chowbay - Drug metabolism reviews, 2009 - Taylor & Francis
Pharmacogenetics is the study of how interindividual variations in the DNA sequence of
specific genes affect drug response. This article highlights current pharmacogenetic …

Aflatoxin B1 metabolism: Regulation by phase I and II metabolizing enzymes and chemoprotective agents

J Deng, L Zhao, NY Zhang, NA Karrow… - … research/reviews in …, 2018 - Elsevier
Abstract Aflatoxin B 1 (AFB 1) widely contaminates staple food and feed crops and is well-
known as the most potent natural hepatocarcinogen in humans and domesticated animals …

A lung/liver-on-a-chip platform for acute and chronic toxicity studies

D Bovard, A Sandoz, K Luettich, S Frentzel, A Iskandar… - Lab on a Chip, 2018 - pubs.rsc.org
The merging of three-dimensional in vitro models with multi-organ-on-a-chip (MOC)
technology has taken in vitro assessment of chemicals to an unprecedented level. By …