Folate absorption is primarily mediated by a membrane transporter with micro-molar
affinities for folates. Paradoxically, folates are only present at low nanomolar concentrations …

Combinatorial association of different lipid species generates microheterogeneity in
biological membranes. The association of glycosphingolipids with cholesterol forms …

Background Most urticarias are induced by vasoactive mediators such as histamine
released from mast cells. Although mast cells are activated by allergens through cross …

Acute stroke induces a local inflammatory reaction causing leukocyte infiltration. Circulating
monocytes are recruited to the ischemic brain and become tissue macrophages …

CD73, otherwise known as ecto-5′-nucleotidase, is a glycosyl-phosphatidylinositol–linked
70-kD molecule expressed on different cell types, including vascular endothelial cells (EC) …

In 1980, it was suggested that alkaline phosphatase Ž. AP interacts with the plasma
membrane via a phoswx pholipid, the phosphatidyl-inositol 1. This was the first real clue of …

The immune system monitors the health of cells and is stimulated by necrosis. Here we
examined the receptors and ligands driving this response. In a targeted screen of C-type …

A number of lymphocyte proteins are attached to the cell membrane via
glycophosphatidylinositol-anchoring domains. Antibodies specific for several of these …

Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal defect in bone marrow-
derived cells and is clinically associated with intravascular hemolysis, hemoglobinuria, and …

How can crosslinking of cell-surface glycosylphosphatidylinositol-anchored proteins activate
T cells when the proteins do not reach the cytosol? Recent results show that …