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Next-generation sequencing is becoming the primary discovery tool in human genetics.
There have been many clear successes in identifying genes that are responsible for …

Background The rational design of modified proteins with controlled stability is of extreme
importance in a whole range of applications, notably in the biotechnological and …

Cancer progression is driven by the accumulation of a small number of genetic alterations.
However, these few driver alterations reside in a cancer genome alongside tens of …

Large‐scale cancer genome sequencing has uncovered thousands of gene mutations, but
distinguishing tumor driver genes from functionally neutral passenger mutations is a major …

Multiple algorithms are used to predict the impact of missense mutations on protein structure
and function using algorithm‐generated sequence alignments or manually curated …

Genomic instability and high mutation rates cause cancer to acquire numerous mutations
and chromosomal alterations during its somatic evolution; most are termed passengers …

Many nonsynonymous single nucleotide polymorphisms (nsSNPs) are disease causing due
to effects at protein‐protein interfaces. We have integrated a database of the three …

Cancer progression is an example of a rapid adaptive process where evolving new traits is
essential for survival and requires a high mutation rate. Precancerous cells acquire a few …

A prime objective of genomic medicine is the identification of disease-causing mutations and
the mechanisms by which such events result in disease. As most disease phenotypes arise …