[HTML][HTML] Role of gut microbiota via the gut-liver-brain axis in digestive diseases

JH Ding, Z Jin, XX Yang, J Lou, WX Shan… - World Journal of …, 2020 - ncbi.nlm.nih.gov
The gut-brain axis is a bidirectional information interaction system between the central
nervous system (CNS) and the gastrointestinal tract, in which gut microbiota plays a key role …

Biogenic amines: signals between commensal microbiota and gut physiology

N Sudo - Frontiers in endocrinology, 2019 - frontiersin.org
There is increasing interest in the interactions among the gut microbiota, gut, and brain,
which is often referred to as the “microbiota-gut-brain” axis. Biogenic amines including …

Neuro-Mesenchymal Interaction Mediated by a β2-Adrenergic Nerve Growth Factor Feedforward Loop Promotes Colorectal Cancer Progression

H Kobayashi, T Iida, Y Ochiai, E Malagola, X Zhi… - Cancer …, 2025 - aacrjournals.org
Cancer-associated fibroblasts (CAF) and nerves, components of the tumor
microenvironment, have each been shown to directly promote gastrointestinal cancers …

Gut-inhabiting Clostridia build human GPCR ligands by conjugating neurotransmitters with diet-and human-derived fatty acids

FY Chang, P Siuti, S Laurent, T Williams… - Nature …, 2021 - nature.com
Human physiology is regulated by endogenous signalling compounds, including fatty acid
amides (FAAs), chemical mimics of which are made by bacteria. The molecules produced by …

[HTML][HTML] Ghrelin signaling affects feeding behavior, metabolism, and memory through the vagus nerve

EA Davis, HS Wald, AN Suarez, J Zubcevic, CM Liu… - Current Biology, 2020 - cell.com
Vagal afferent neuron (VAN) signaling sends information from the gut to the brain and is
fundamental in the control of feeding behavior and metabolism [1]. Recent findings reveal …

Sympathetic activity regulates epithelial proliferation and wound healing via adrenergic receptor α2A

AS Ten Hove, S Mallesh, K Zafeiropoulou… - Scientific reports, 2023 - nature.com
Innervation of the intestinal mucosa by the sympathetic nervous system is well described but
the effects of adrenergic receptor stimulation on the intestinal epithelium remain equivocal …

Hair follicle stem cells as a skin‐organizing signaling center during adult homeostasis

KN Li, T Tumbar - The EMBO Journal, 2021 - embopress.org
Stem cells are the essential source of building blocks for tissue homeostasis and
regeneration. Their behavior is dictated by both cell‐intrinsic cues and extrinsic cues from …

Neuroimmune interactions in the gut and their significance for intestinal immunity

DJ Brinkman, AS Ten Hove, MJ Vervoordeldonk… - Cells, 2019 - mdpi.com
Inflammatory bowel diseases (IBD) have a complex, multifactorial pathophysiology with an
unmet need for effective treatment. This calls for novel strategies to improve disease …

The sympathetic nervous system drives hyperinflammatory responses to Clostridioides difficile infection

D Tyus, JL Leslie, F Naz, MJ Uddin, B Thompson… - Cell Reports …, 2024 - cell.com
Clostridioides difficile infection (CDI) is a leading cause of hospital-acquired infections in the
United States, known for triggering severe disease by hyperactivation of the host response …

Regulation of the autonomic nervous system on intestine

H Duan, X Cai, Y Luan, S Yang, J Yang… - Frontiers in …, 2021 - frontiersin.org
Intestine is composed of various types of cells including absorptive epithelial cells, goblet
cells, endocrine cells, Paneth cells, immunological cells, and so on, which play digestion …