A bacterial immunity protein directly senses two disparate phage proteins
Eukaryotic innate immune systems use pattern recognition receptors to sense infection by
detecting pathogen-associated molecular patterns, which then triggers an immune …
detecting pathogen-associated molecular patterns, which then triggers an immune …
Conformational change as a mechanism for toxin activation in bacterial toxin-antitoxin systems
V Sanchez-Torres, HJ Hwang, TK Wood - Journal of Virology, 2024 - journals.asm.org
Toxin/antitoxin (TA) systems are present in nearly every prokaryotic genome and play the
important physiological roles of phage inhibition by reducing metabolism (this includes …
important physiological roles of phage inhibition by reducing metabolism (this includes …
Anti-viral defence by an mRNA ADP-ribosyltransferase that blocks translation
CN Vassallo, CR Doering, MT Laub - Nature, 2024 - nature.com
Host–pathogen conflicts are crucibles of molecular innovation,. Selection for immunity to
pathogens has driven the evolution of sophisticated immunity mechanisms throughout …
pathogens has driven the evolution of sophisticated immunity mechanisms throughout …
Toxic small alarmone synthetase FaRel2 inhibits translation by pyrophosphorylating tRNAGly and tRNAThr
T Kurata, M Takegawa, T Ohira, EA Syroegin… - Science …, 2024 - science.org
Translation-targeting toxic small alarmone synthetases (toxSAS) are effectors of bacterial
toxin-antitoxin systems that pyrophosphorylate the 3′-CCA end of transfer RNA (tRNA) to …
toxin-antitoxin systems that pyrophosphorylate the 3′-CCA end of transfer RNA (tRNA) to …
Bacteria renew an OLD protein to cleave host tRNAs and block phage translation
Anti-phage defenses must rapidly sense and respond to diverse viruses. A recent pair of
papers in Nature reveal via structural and functional assays how the PARIS defense system …
papers in Nature reveal via structural and functional assays how the PARIS defense system …
Chaperones help TACkle phage infection
SR Margolis, AJ Meeske - Cell Host & Microbe, 2024 - Elsevier
Bacteria have evolved anti-viral defenses, but the mechanisms of sensing and stopping
infection are still under investigation. In this issue of Cell Host & Microbe, Mets, Kurata, Ernits …
infection are still under investigation. In this issue of Cell Host & Microbe, Mets, Kurata, Ernits …