Multiple system atrophy (MSA) is an orphan, fatal, adult-onset neurodegenerative disorder of
uncertain etiology that is clinically characterized by various combinations of parkinsonism …

Multiple system atrophy (MSA) is a debilitating and fatal neurodegenerative disorder. The
disease severity warrants urgent development of disease-modifying therapy, but the disease …

Multiple system atrophy (MSA) is a sporadic orphan neurodegenerative disorder. No
treatment is currently available to slow down the aggressive neurodegenerative process …

Multiple system atrophy (MSA) is a unique proteinopathy that differs from other α-
synucleinopathies since the pathological process resulting from accumulation of aberrant α …

Introduction: Multiple system atrophy (MSA), an adult-onset, fatal disorder of uncertain
etiology, characterized by parkinsonism, cerebellar, autonomic and motor dysfunctions, is an …

Unwarranted exposure due to liberal use of metals for maintaining the lavish life and to
achieve the food demand for escalating population along with an incredible boost in the …

Multiple system atrophy (MSA) is a fatal orphan neurodegenerative disorder that manifests
with autonomic, parkinsonian, cerebellar, and pyramidal features. It is characterized by the …

Abstract α-Synuclein is an abundantly expressed protein located in the neuronal synapse
which accumulates in Lewy body inclusions and synaptic aggregates in neurodegenerative …

Abstract α-synucleinopathies are a subset of progressive neurodegenerative disorders that
share several features and, above all, α-synuclein (α-syn) accumulation. Lewy bodies and …

The synucleins pertain to a family of highly conserved proteins expressed only in vertebrates
and encoded by three distinct genes, α-synuclein (α-syn), β-synuclein, and γ-synuclein. The …