Pharmacology and therapeutics of bronchodilators

M Cazzola, CP Page, L Calzetta, MG Matera… - Pharmacological …, 2012 - Elsevier
Bronchodilators are central in the treatment of of airways disorders. They are the mainstay of
the current management of chronic obstructive pulmonary disease (COPD) and are critical in …

Brain natriuretic peptide: much more than a biomarker

L Calzetta, A Orlandi, C Page, P Rogliani… - International journal of …, 2016 - Elsevier
Brain natriuretic peptide (BNP) modulates several biological processes by activating the
natriuretic peptide receptor A (NPR-A). Atria and ventricles secrete BNP. BNP increases …

[图书][B] Inhalation aerosols: physical and biological basis for therapy

AJ Hickey, HM Mansour - 2019 - books.google.com
Inhalation aerosols continue to be the basis for successful lung therapy for several diseases,
with therapeutic strategies and the range of technology significantly evolving in recent years …

Epithelium integrity is crucial for the relaxant activity of brain natriuretic peptide in human isolated bronchi

MG Matera, L Calzetta, D Passeri… - British journal of …, 2011 - Wiley Online Library
BACKGROUND AND PURPOSE Brain natriuretic peptide (BNP) plays an important role in
several biological functions, including bronchial relaxation. Here, we have investigated the …

Assessment of dyspnea in acute decompensated heart failure: insights from ASCEND-HF (Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart …

JA Ezekowitz, AF Hernandez, CM O'Connor… - Journal of the American …, 2012 - jacc.org
Objectives: This study hypothesized that peak expiratory flow rate (PEFR) would increase
with acute heart failure (AHF) treatment over the first 24 h, related to a Dyspnea Index (DI) …

Advances in understanding of mechanisms related to increased cardiovascular risk in COPD

P Rogliani, BL Ritondo, R Laitano… - Expert Review of …, 2021 - Taylor & Francis
Introduction Chronic obstructive pulmonary disease (COPD) represents a serious global
health issue that is commonly associated with cardiovascular (CV) disease (CVD). The close …

Endocrine regulation of airway contractility is overlooked

Y Bossé - Journal of Endocrinology, 2014 - joe.bioscientifica.com
Asthma is a prevalent respiratory disorder triggered by a variety of inhaled environmental
factors, such as allergens, viruses, and pollutants. Asthma is characterized by an elevated …

In vitro and in vivo pharmacological profile of PL-3994, a novel cyclic peptide (Hept-cyclo (Cys-His-Phe-d-Ala-Gly-Arg-d-Nle-Asp-Arg-Ile-Ser-Cys)-Tyr-[Arg mimetic] …

JD Edelson, M Makhlina, KR Silvester… - Pulmonary …, 2013 - Elsevier
The pharmacological and airways relaxant profiles of PL-3994 (Hept-cyclo (Cys-His-Phe-d-
Ala-Gly-Arg-d-Nle-Asp-Arg-Ile-Ser-Cys)-Tyr-[Arg mimetic]-NH2), a novel natriuretic peptide …

Clinical implications of defective B‐type natriuretic peptide

SG Menon, RM Mills, U Schellenberger… - Clinical …, 2009 - Wiley Online Library
Our understanding of the natriuretic peptide system continues to evolve rapidly. B‐type
natriuretic peptide (BNP), originally thought to be a simple volume‐regulating hormone that …

Asthma: new developments concerning immune mechanisms, diagnosis and treatment

RM Effros, H Nagaraj - Current opinion in pulmonary medicine, 2007 - journals.lww.com
Greater insight into the mechanisms responsible for asthma and the introduction of new
drugs will depend in part upon the development of reliable and simple methods for detecting …