Clinical epigenetics: seizing opportunities for translation

M Berdasco, M Esteller - Nature Reviews Genetics, 2019 - nature.com
Biomarker discovery and validation are necessary for improving the prediction of clinical
outcomes and patient monitoring. Despite considerable interest in biomarker discovery and …

Maternal obesity, diabetes during pregnancy and epigenetic mechanisms that influence the developmental origins of cardiometabolic disease in the offspring

P Agarwal, TS Morriseau, SM Kereliuk… - Critical reviews in …, 2018 - Taylor & Francis
Since 1980, global obesity has doubled, and the incidence of cardiometabolic diseases
such as type 2 diabetes and heart disease is also increasing. While genetic susceptibility …

Asupan protein, ZAT besi dan status gizi pada remaja PUTRI

MP Putri, D Dary, G Mangalik - Journal of Nutrition College, 2022 - ejournal3.undip.ac.id
Latar belakang: Asupan zat besi dan protein berperan penting untuk pertumbuhan pada
masa remaja. Asupan zat gizi yang tidak seimbang dapat mengakibatkan masalah gizi …

Maternal β-cell adaptations in pregnancy and placental signalling: implications for gestational diabetes

BL Moyce, VW Dolinsky - International journal of molecular sciences, 2018 - mdpi.com
Rates of gestational diabetes mellitus (GDM) are on the rise worldwide, and the number of
pregnancies impacted by GDM and resulting complications are also increasing. Pregnancy …

[HTML][HTML] Modeling the western diet for preclinical investigations

KJ Hintze, AD Benninghoff, CE Cho, RE Ward - Advances in Nutrition, 2018 - Elsevier
Rodent models have been invaluable for biomedical research. Preclinical investigations
with rodents allow researchers to investigate diseases by using study designs that are not …

Recent experimental studies of maternal obesity, diabetes during pregnancy and the developmental origins of cardiovascular disease

SM Kereliuk, VW Dolinsky - International Journal of Molecular Sciences, 2022 - mdpi.com
Globally, cardiovascular disease remains the leading cause of death. Most concerning is the
rise in cardiovascular risk factors including obesity, diabetes and hypertension among youth …

Maternal dietary quality and dietary inflammation associations with offspring growth, placental development, and DNA methylation

M Lecorguillé, S Teo, CM Phillips - Nutrients, 2021 - mdpi.com
The 'Developmental Origins of Health and Diseases' hypothesis posits that prenatal
maternal diet influences offspring growth and later life health outcomes. Dietary assessment …

They are what you eat: can nutritional factors during gestation and early infancy modulate the neonatal immune response?

S Prentice - Frontiers in immunology, 2017 - frontiersin.org
The ontogeny of the human immune system is sensitive to nutrition even in the very early
embryo, with both deficiency and excess of macro-and micronutrients being potentially …

Epidrugs in the therapy of central nervous system disorders: a way to drive on?

MG Gladkova, E Leidmaa, EA Anderzhanova - Cells, 2023 - mdpi.com
The polygenic nature of neurological and psychiatric syndromes and the significant impact
of environmental factors on the underlying developmental, homeostatic, and neuroplastic …

Maternal androgen excess induces cardiac hypertrophy and left ventricular dysfunction in female mice offspring

M Manti, R Fornes, G Pironti… - Cardiovascular …, 2020 - academic.oup.com
Aims Polycystic ovary syndrome (PCOS) is a common endocrinopathy that is suggested to
increase the risk for cardiovascular disease. How PCOS may lead to adverse cardiac …