Glutamate is the most abundant free amino acid in the brain and is at the crossroad between
multiple metabolic pathways. Considering this, it was a surprise to discover that glutamate …

The sodium-coupled neutral amino acid transporters (SNAT) of the SLC38 gene family
resemble the classically-described System A and System N transport activities in terms of …

Glutamine is an essential cerebral metabolite. Several critical brain processes are directly
linked to glutamine, including ammonia homeostasis, energy metabolism and …

Three closely related proteins transport glutamate into synaptic vesicles for release by
exocytosis. Complementary patterns of expression in glutamatergic terminals have been …

Altered metabolism is a hallmark of cancer cells. Tumor cells rewire their metabolism to
support their uncontrolled proliferation by taking up nutrients from the microenvironment …

Malignant gliomas are relentless tumors that offer a dismal clinical prognosis. They develop
many biological advantages that allow them to grow and survive in the unique environment …

Glucose is essentially the sole fuel for the adult brain and the mapping of its metabolism has
been extensive in the adult but not in the neonatal brain, which is believed to rely mainly on …

L-glutamine (Gln) is the most abundant amino acid in plasma and cerebrospinal fluid and a
precursor for the main central nervous system excitatory (L-glutamate) and inhibitory (γ …

Blood–brain barrier formed by brain capillary endothelial cells, being in contact with
astrocytes endfeet and pericytes, separates extracellular fluid from plasma. Supply of …

Glutamine is a key amino acid in the CNS, playing an important role in the glutamate/GABA–
glutamine cycle (GGC). In the GGC, glutamine is transferred from astrocytes to neurons …