Simple Summary Cells undergoing malignant transformation must circumvent replicative
senescence and eventual cell death associated with progressive telomere shortening that …

Deuterium metabolic imaging (DMI) is an emerging clinically-applicable technique for the
non-invasive investigation of tissue metabolism. The generally short T 1 values of 2 H …

Transformed cells must acquire specific characteristics to be malignant. Weinberg and
Hanahan characterize these characteristics as cancer hallmarks. Though these features are …

Aging biomarkers are a combination of biological parameters to (i) assess age-related
changes,(ii) track the physiological aging process, and (iii) predict the transition into a …

Purpose: Telomere maintenance is a hallmark of cancer. Most tumors maintain telomere
length via reactivation of telomerase reverse transcriptase (TERT) expression. Identifying …

Programmed cell death is pivotal for several physiological processes, including immune
defense. Further, it has been implicated in the pathogenesis of developmental disorders and …

Background The alternative lengthening of telomeres (ALT) pathway is essential for tumor
proliferation in astrocytomas. The goal of this study was to identify metabolic alterations …

Proton magnetic resonance spectroscopy (1H-MRS) provides a non-invasive biochemical
profile of brain tumors. The conventional 1H-MRS methods present a few challenges mainly …

Cuproptosis is characterized by lipoylated protein aggregation and loss of iron–sulfur (Fe–S)
proteins, which are crucial for a wide range of important cellular functions, including DNA …

Endowing current artificial chemical reactions (ACRs) with high specificity and intricate
activation capabilities is crucial for expanding their applications in accurate bioimaging …