Ageing and rejuvenation of tissue stem cells and their niches

A Brunet, MA Goodell, TA Rando - Nature Reviews Molecular Cell …, 2023 - nature.com
Most adult organs contain regenerative stem cells, often organized in specific niches. Stem
cell function is critical for tissue homeostasis and repair upon injury, and it is dependent on …

Gut microbiota in colorectal cancer development and therapy

CC Wong, J Yu - Nature Reviews Clinical Oncology, 2023 - nature.com
Colorectal cancer (CRC) is one of the commonest cancers globally. A unique aspect of CRC
is its intimate association with the gut microbiota, which forms an essential part of the tumour …

Lung adenocarcinoma promotion by air pollutants

W Hill, EL Lim, CE Weeden, C Lee, M Augustine… - Nature, 2023 - nature.com
A complete understanding of how exposure to environmental substances promotes cancer
formation is lacking. More than 70 years ago, tumorigenesis was proposed to occur in a two …

YAP/TAZ as master regulators in cancer: modulation, function and therapeutic approaches

S Piccolo, T Panciera, P Contessotto, M Cordenonsi - Nature cancer, 2023 - nature.com
Our understanding of the function of the transcriptional regulators YAP and TAZ (YAP/TAZ)
in cancer is advancing. In this Review, we provide an update on recent progress in YAP/TAZ …

Young-onset colorectal cancer

MCW Spaander, AG Zauber, S Syngal… - Nature reviews Disease …, 2023 - nature.com
In the past decades the incidence of colorectal cancer (CRC) in people under the age of 50
years has increased, which is referred to as early-onset CRC or young-onset CRC (YO …

Life histories of myeloproliferative neoplasms inferred from phylogenies

N Williams, J Lee, E Mitchell, L Moore, EJ Baxter… - Nature, 2022 - nature.com
Mutations in cancer-associated genes drive tumour outgrowth, but our knowledge of the
timing of driver mutations and subsequent clonal dynamics is limited,–. Here, using whole …

The coming decade in precision oncology: six riddles

A Wahida, L Buschhorn, S Fröhling, PJ Jost… - Nature Reviews …, 2023 - nature.com
High-throughput methods to investigate tumour omic landscapes have quickly catapulted
cancer specialists into the precision oncology era. The singular lesson of precision oncology …

Somatic genomic changes in single Alzheimer's disease neurons

MB Miller, AY Huang, J Kim, Z Zhou, SL Kirkham… - Nature, 2022 - nature.com
Dementia in Alzheimer's disease progresses alongside neurodegeneration,,–, but the
specific events that cause neuronal dysfunction and death remain poorly understood. During …

[HTML][HTML] Clonal dynamics of haematopoiesis across the human lifespan

E Mitchell, M Spencer Chapman, N Williams… - Nature, 2022 - nature.com
Age-related change in human haematopoiesis causes reduced regenerative capacity,
cytopenias, immune dysfunction and increased risk of blood cancer,–, but the reason for …

Spatial biology of cancer evolution

Z Seferbekova, A Lomakin, LR Yates… - Nature Reviews …, 2023 - nature.com
The natural history of cancers can be understood through the lens of evolution given that the
driving forces of cancer development are mutation and selection of fitter clones. Cancer …