Sexual dimorphism in placental development and its contribution to health and diseases

P Yu, Y Chen, C Ge, H Wang - Critical reviews in toxicology, 2021 - Taylor & Francis
Abstract According to the Developmental Origin of Health and Disease (DOHaD),
intrauterine exposure to adverse environments can affect fetus and birth outcomes and lead …

Placental genomics mediates genetic associations with complex health traits and disease

A Bhattacharya, AN Freedman, V Avula… - Nature …, 2022 - nature.com
As the master regulator in utero, the placenta is core to the Developmental Origins of Health
and Disease (DOHaD) hypothesis but is historically understudied. To identify placental gene …

The placenta's role in sexually dimorphic fetal growth strategies

JK Christians - Reproductive Sciences, 2022 - Springer
Fetal sex affects the risk of pregnancy complications and the long-term effects of prenatal
environment on health. Some have hypothesized that growth strategies differ between the …

[HTML][HTML] Wildfires and extracellular vesicles: Exosomal MicroRNAs as mediators of cross-tissue cardiopulmonary responses to biomass smoke

CK Carberry, LE Koval, A Payton, H Hartwell… - Environment …, 2022 - Elsevier
Introduction Wildfires are a threat to public health world-wide that are growing in intensity
and prevalence. The biological mechanisms that elicit wildfire-associated toxicity remain …

Sex-based differences in placental DNA methylation profiles related to gestational age: an NIH ECHO meta-analysis

CM Bulka, TM Everson, AA Burt, CJ Marsit… - Epigenetics, 2023 - Taylor & Francis
The placenta undergoes many changes throughout gestation to support the evolving needs
of the foetus. There is also a growing appreciation that male and female foetuses develop …

The placenta epigenome–brain axis: placental epigenomic and transcriptomic responses that preprogram cognitive impairment

AN Freedman, LA Eaves, JE Rager… - …, 2022 - Taylor & Francis
Aim: The placenta–brain axis reflects a developmental linkage where disrupted placental
function is associated with impaired neurodevelopment later in life. Placental gene …

Evidence for the placenta-brain axis: multi-omic kernel aggregation predicts intellectual and social impairment in children born extremely preterm

HP Santos Jr, A Bhattacharya, RM Joseph, L Smeester… - Molecular Autism, 2020 - Springer
Background Children born extremely preterm are at heightened risk for intellectual and
social impairment, including Autism Spectrum Disorder (ASD). There is increasing evidence …

Placental transcriptional signatures associated with cerebral white matter damage in the neonate

CA Marable, K Roell, K Kuban, TM O'Shea… - Frontiers in …, 2022 - frontiersin.org
Cerebral white matter is the most common anatomic location of neonatal brain injury in
preterm newborns. Factors that predispose preterm newborns to white matter damage are …

Prenatal Metal Exposure Alters the Placental Proteome in a Sex-Dependent Manner in Extremely Low Gestational Age Newborns: Links to Gestational Age

AN Freedman, K Roell, E Engwall, C Bulka… - International Journal of …, 2023 - mdpi.com
Prenatal exposure to toxic metals is associated with altered placental function and adverse
infant and child health outcomes. Adverse outcomes include those that are observed at the …

Comparing the predictivity of human placental gene, microRNA, and CpG methylation signatures in relation to perinatal outcomes

J Clark, V Avula, C Ring, LA Eaves… - Toxicological …, 2021 - academic.oup.com
Molecular signatures are being increasingly integrated into predictive biology applications.
However, there are limited studies comparing the overall predictivity of transcriptomic versus …