Adults with Down syndrome develop the neuropathological hallmarks of Alzheimer's
disease and are at very high risk of developing early-onset dementia, which is now the …

Individuals with Down syndrome (DS) have an increased risk for epilepsy during the whole
lifespan, but especially after age 40 years. The increase in the number of individuals with DS …

Sleep disturbances are complex elements of many neurodevelopmental disorders, such as
autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), intellectual …

Improved medical care of individuals with Down syndrome (DS) has led to an increase in life
expectancy to over the age of 60 years. In conjunction, there has been an increase in age …

Autosomal dominant Alzheimer's disease (ADAD) and Down syndrome (DS) constitute
genetic forms of Alzheimer's disease (AD). The study of these forms has been crucial in …

Abstract Introduction The SPIN (Sant Pau Initiative on Neurodegeneration) cohort is a
multimodal biomarker platform designed for neurodegenerative disease research following …

There are multiple disorders of neurodevelopment that present with co-occurring sleep
disturbances. Many of these neurodevelopmental disorders (NDD) include sleep …

Down syndrome (DS) is the main genetic cause of intellectual disability worldwide. The
overexpression of the Amyloid Precursor Protein, present in chromosome 21, leads to β …

Down syndrome (DS) results in various degrees of cognitive deficits. In DS mouse models,
recovery of behavioral and neurophysiological deficits using GABAAR antagonists led to …

Sleep disorders, despite being very frequent in adults with Down syndrome (DS), are often
overlooked due to a lack of awareness by families and physicians and the absence of …