The toxicity of oxygen and nitrogen reactive species appears to be merely the tip of the
iceberg in the world of redox homeostasis. Now, oxidative stress can be seen as a two-sided …

Chagas Disease, African sleeping sickness, and leishmaniasis are neglected diseases
caused by pathogenic trypanosomatid parasites, which have a considerable impact on …

Gene expression in Plasmodia integrates post-transcriptional regulation with epigenetic
marking of active genomic regions through histone post-translational modifications (PTMs) …

Nucleosomes composed of histones are the fundamental units around which DNA is
wrapped to form chromatin. Transcriptionally active euchromatin or repressive …

Histone variants play a crucial role in chromatin structure organization and gene expression.
Trypanosomatids have an unusual H2B variant (H2B. V) that is known to dimerize with the …

Protein acetylation is a post-translational modification regulating diverse cellular processes.
By using proteomic approaches, we identified N-terminal and ε-lysine acetylated proteins in …

Trypanosome histone N-terminal sequences are very divergent from the other eukaryotes,
although they are still decorated by post-translational modifications (PTMs). Here, we used a …

Chagas disease, caused by Trypanosoma cruzi, still affects millions of people around the
world. No vaccines nor treatment for chronic Chagas disease are available, and …

Histone posttranslational modifications (PTMs) modulate several eukaryotic cellular
processes, including transcription, replication, and repair. Vast arrays of modifications have …

Mass spectrometry-based proteomics enables accurate measurement of the modulations of
proteins on a large scale upon perturbation and facilitates the understanding of the …