[HTML][HTML] Hypoxia Pathways in Parkinson's Disease: From Pathogenesis to Therapeutic Targets

Y Gao, J Zhang, T Tang, Z Liu - International Journal of Molecular …, 2024 - mdpi.com
The human brain is highly dependent on oxygen, utilizing approximately 20% of the body's
oxygen at rest. Oxygen deprivation to the brain can lead to loss of consciousness within …

Nuclear proteostasis imbalance in laminopathy‐associated premature aging diseases

S Pande, DK Ghosh - The FASEB Journal, 2023 - Wiley Online Library
Laminopathies are a group of rare genetic disorders with heterogeneous clinical
phenotypes such as premature aging, cardiomyopathy, lipodystrophy, muscular dystrophy …

[HTML][HTML] Hydroxyurea interaction with α7 nicotinic acetylcholine receptor can underlie its therapeutic efficacy upon COVID-19

O Lykhmus, O Kalashnyk, R Sullivan Jr… - Journal of …, 2023 - Elsevier
In this paper the authors provide evidence that hydroxyurea (hydroxycarbamide) interacts
with α7 nicotinic acetylcholine receptor, exerts anti-inflammatory and pro-survival effect …

The role of α7 nicotinic acetylcholine receptors in post-acute sequelae of covid-19

M Skok - The International Journal of Biochemistry & Cell …, 2024 - Elsevier
Abstract Post-Acute Sequelae of COVID-19 or Long COVID becomes evident some weeks to
months following acute COVID-19. Symptoms include cognitive impairment and varying …

[HTML][HTML] p53/HIF-1α regulates neuronal aging and autophagy in spinal cord ischemia/reperfusion injury

X Liu, J Wang, K Shen, W Jin - Mechanisms of Ageing and Development, 2024 - Elsevier
Objection Spinal cord injury (SCI)-induced hindlimb dysfunction affects the physical and
mental health of patients. There is growing evidence suggesting that the recovery capacity of …

Activation of α7 Nicotinic Acetylcholine Receptor Improves Muscle Endurance by Upregulating Orosomucoid Expression and Glycogen Content in Mice

F Chen, Z Zhang, H Zhang, P Guo… - Journal of Cellular …, 2024 - Wiley Online Library
There are presently no acknowledged therapeutic targets or official drugs for the treatment of
muscle fatigue. The alpha7 nicotinic acetylcholine receptor (α7nAChR) is expressed in …

Integrative Pharmacology in the Treatment of Substance Use Disorders

J Donlon, P Kumari, SP Varghese, M Bai… - Journal of Dual …, 2024 - Taylor & Francis
The detrimental physical, mental, and socioeconomic effects of substance use disorders
(SUDs) have been apparent to the medical community for decades. However, it has become …