Molecular basis of atrial fibrillation pathophysiology and therapy: a translational perspective

S Nattel, J Heijman, L Zhou, D Dobrev - Circulation research, 2020 - Am Heart Assoc
Atrial fibrillation (AF) is a highly prevalent arrhythmia, with substantial associated morbidity
and mortality. There have been significant management advances over the past 2 decades …

Cellular and molecular electrophysiology of atrial fibrillation initiation, maintenance, and progression

J Heijman, N Voigt, S Nattel, D Dobrev - Circulation research, 2014 - Am Heart Assoc
Atrial fibrillation (AF) is the most common clinically relevant arrhythmia and is associated
with increased morbidity and mortality. The incidence of AF is expected to continue to rise …

Pathophysiological mechanisms of atrial fibrillation: a translational appraisal

U Schotten, S Verheule, P Kirchhof… - Physiological …, 2011 - journals.physiology.org
Atrial fibrillation (AF) is an arrhythmia that can occur as the result of numerous different
pathophysiological processes in the atria. Some aspects of the morphological and …

Recent advances in the molecular pathophysiology of atrial fibrillation

R Wakili, N Voigt, S Kääb, D Dobrev… - The Journal of clinical …, 2011 - Am Soc Clin Investig
Atrial fibrillation (AF) is an extremely common cardiac rhythm disorder that causes
substantial morbidity and contributes to mortality. The mechanisms underlying AF are …

Molecular background of leak K+ currents: two-pore domain potassium channels

P Enyedi, G Czirják - Physiological reviews, 2010 - journals.physiology.org
Two-pore domain K+(K 2P) channels give rise to leak (also called background) K+ currents.
The well-known role of background K+ currents is to stabilize the negative resting …

Connexins in cardiovascular and neurovascular health and disease: pharmacological implications

L Leybaert, PD Lampe, S Dhein, BR Kwak… - Pharmacological …, 2017 - Elsevier
Connexins are ubiquitous channel forming proteins that assemble as plasma membrane
hemichannels and as intercellular gap junction channels that directly connect cells. In the …

Atrial remodeling and atrial fibrillation: mechanisms and implications

S Nattel, B Burstein, D Dobrev - Circulation: Arrhythmia and …, 2008 - Am Heart Assoc
Atrial fibrillation (AF) is the most common arrhythmia in clinical practice. It can occur at any
age but is very rare in children and becomes extremely common in the elderly, with a …

Arrhythmogenic ion-channel remodeling in the heart: heart failure, myocardial infarction, and atrial fibrillation

S Nattel, A Maguy, S Le Bouter… - Physiological …, 2007 - journals.physiology.org
Rhythmic and effective cardiac contraction depends on appropriately timed generation and
spread of cardiac electrical activity. The basic cellular unit of such activity is the action …

[图书][B] Cardiac electrophysiology: from cell to bedside E-book

DP Zipes, J Jalife, WG Stevenson - 2017 - books.google.com
Rapid advancements in cardiac electrophysiology require today's health care scientists and
practitioners to stay up to date with new information both at the bench and at the bedside …

Calcium in the pathophysiology of atrial fibrillation and heart failure

NC Denham, CM Pearman, JL Caldwell… - Frontiers in …, 2018 - frontiersin.org
Atrial fibrillation (AF) is commonly associated with heart failure. A bidirectional relationship
exists between the two—AF exacerbates heart failure causing a significant increase in heart …