[HTML][HTML] High-throughput proteomics: a methodological mini-review

M Cui, C Cheng, L Zhang - Laboratory investigation, 2022 - Elsevier
Proteomics plays a vital role in biomedical research in the post-genomic era. With the
technological revolution and emerging computational and statistic models, proteomic …

Trends in the approval of cancer therapies by the FDA in the twenty-first century

EC Scott, AC Baines, Y Gong, R Moore Jr… - Nature Reviews Drug …, 2023 - nature.com
The cancer treatment landscape has changed dramatically since the turn of the century,
resulting in substantial improvements in outcomes for patients. This Review summarizes …

Proksee: in-depth characterization and visualization of bacterial genomes

JR Grant, E Enns, E Marinier, A Mandal… - Nucleic acids …, 2023 - academic.oup.com
Abstract Proksee (https://proksee. ca) provides users with a powerful, easy-to-use, and
feature-rich system for assembling, annotating, analysing, and visualizing bacterial …

A lymphocyte–microglia–astrocyte axis in chronic active multiple sclerosis

M Absinta, D Maric, M Gharagozloo, T Garton… - Nature, 2021 - nature.com
Multiple sclerosis (MS) lesions that do not resolve in the months after they form harbour
ongoing demyelination and axon degeneration, and are identifiable in vivo by their …

Predictive performance of presence‐only species distribution models: a benchmark study with reproducible code

R Valavi, G Guillera‐Arroita… - Ecological …, 2022 - Wiley Online Library
Species distribution modeling (SDM) is widely used in ecology and conservation. Currently,
the most available data for SDM are species presence‐only records (available through …

[PDF][PDF] Lymph node colonization induces tumor-immune tolerance to promote distant metastasis

NE Reticker-Flynn, W Zhang, JA Belk, PA Basto… - Cell, 2022 - cell.com
For many solid malignancies, lymph node (LN) involvement represents a harbinger of
distant metastatic disease and, therefore, an important prognostic factor. Beyond its utility as …

Expanding known viral diversity in the healthy infant gut

SA Shah, L Deng, J Thorsen, AG Pedersen… - Nature …, 2023 - nature.com
The gut microbiome is shaped through infancy and impacts the maturation of the immune
system, thus protecting against chronic disease later in life. Phages, or viruses that infect …

Genome-scale metabolic reconstruction of 7,302 human microorganisms for personalized medicine

A Heinken, J Hertel, G Acharya, DA Ravcheev… - Nature …, 2023 - nature.com
The human microbiome influences the efficacy and safety of a wide variety of commonly
prescribed drugs. Designing precision medicine approaches that incorporate microbial …

From telomere to telomere: The transcriptional and epigenetic state of human repeat elements

SJ Hoyt, JM Storer, GA Hartley, PGS Grady… - Science, 2022 - science.org
Mobile elements and repetitive genomic regions are sources of lineage-specific genomic
innovation and uniquely fingerprint individual genomes. Comprehensive analyses of such …

Autocrine vitamin D signaling switches off pro-inflammatory programs of TH1 cells

D Chauss, T Freiwald, R McGregor, B Yan, L Wang… - Nature …, 2022 - nature.com
The molecular mechanisms governing orderly shutdown and retraction of CD4+ type 1
helper T (TH1) cell responses remain poorly understood. Here we show that complement …