Over the past 20 years, the Global Initiative for Asthma (GINA) has regularly published and
annually updated a global strategy for asthma management and prevention that has formed …

Background Previous systematic reviews have not shown clear benefit of glucocorticoids for
acute viral bronchiolitis, but their use remains considerable. Recent large trials add …

Preschool children (ie, those aged 5 years or younger) with wheeze consume a
disproportionately high amount of health-care resources compared with older children and …

Rationale: Preschool wheezing is heterogeneous, but the underlying mechanisms are
poorly understood. Objectives: To investigate lower airway inflammation and infection in …

Rationale: Respiratory syncytial virus (RSV) induces not only infantile recurrent wheezing
but also potentially atopic asthma. Objectives: To test the effect of RSV infection on …

In the pathogenesis of asthma in children there is a pivotal role for a type 2 inflammatory
response to early life exposures or events. Interactions between infections, atopy, genetic …

It is difficult to distinguish at preschool age whether a wheezing child will or will not have
asthma at school age. A prediction rule for asthma in preschool children might help to …

Asthma exacerbations and severe asthma are linked with high morbidity, significant mortality
and high treatment costs. Recurrent asthma exacerbations cause a decline in lung function …

Asthma is a common disease in young children and is associated with significant morbidity
and an increasing prevalence over time. Early childhood wheezing and asthma are …

It has been suggested that there are several distinct phenotypes of childhood asthma or
childhood wheezing. Here, we review the research relating to these phenotypes, with a …