The kidneys play a key role in maintaining total body homeostasis. The complexity of this
task is reflected in the unique architecture of the organ. Ureteral obstruction greatly affects …

Acute kidney injury (AKI) is a major public health concern associated with high morbidity and
mortality. Despite decades of research, the pathogenesis of AKI remains incompletely …

Abstract Knowledge of cell type composition in disease relevant tissues is an important step
towards the identification of cellular targets of disease. We present MuSiC, a method that …

Though an acute kidney injury (AKI) episode is associated with an increased risk of chronic
kidney disease (CKD), the mechanisms determining the transition from acute to irreversible …

Bioinformatic analysis can not only accelerate drug target identification and drug candidate
screening and refinement, but also facilitate characterization of side effects and predict drug …

The glucagon receptor (GCGR) in the kidney is expressed in nephron tubules. In humans
and animal models with chronic kidney disease, renal GCGR expression is reduced …

Renal fibrosis is a key factor in chronic kidney disease (CKD). Long non-coding RNAs
(lncRNAs) play important roles in the physiological and pathological progression of human …

Transforming growth factor-β/Smad signaling plays an important role in diabetic
nephropathy. The current study identified a novel Smad3-dependent long noncoding RNA …

Acute kidney injury (AKI) is an important health issue concerning∼ 50% of patients treated
in intensive care units. AKI mainly occurs after sepsis, acute ischemia, nephrotoxicity, or …

The occurrence of a spontaneous nephropathy with intranuclear inclusions in laboratory
mice has puzzled pathologists for over 4 decades, because its etiology remains elusive. The …