Cellular oxidation–reduction (redox) systems, which encompass pro‐and antioxidant
molecules, are integral components of a plethora of essential cellular processes. Any …

H 2 O 2 signals trigger adaptive responses affecting cell division, differentiation, migration,
and survival. These signals are transduced by selective oxidation of cysteines on specific …

Biological milieus are highly crowded and heterogeneous systems where organization of
macromolecules within nanodomains (eg membraneless compartments) is vital to the …

Cellular homeostasis is continuously challenged by environmental cues and cellular stress
conditions. In their defense, cells need to mount appropriate stress responses that …

Abstract Paracrine superoxide (O 2•−) and hydrogen peroxide (H 2 O 2) signaling critically
depends on these substances' concentrations, half-lives and transport ranges in …

Growing evidence suggests that dimethylarginine dimethylaminohydrolase 1 (DDAH1), a
crucial enzyme for the degradation of asymmetric dimethylarginine (ADMA), is closely …

In the cytosol of human cells under low oxidative loads, hydrogen peroxide is confined to
microdomains around its supply sites, due to its fast consumption by peroxiredoxins. So are …

Peroxiredoxins (Prdxs) are thiol-dependent enzymes that scavenge peroxides. Previously,
we found that Prdxs were hyperoxidized in a Parkinson's disease model induced by …

Macrophages are characterised by their high plasticity and ability to adapt their phenotype
and functionality in response to environmental cues, resulting in a spectrum of activation …

Hydrogen peroxide (H2O2) plays a central role in cellular signaling, but its signaling
mechanisms are just beginning to be understood. Here we analyze and review the evidence …