Biginelli reaction: an overview
Biginelli reaction involves acid-catalyzed one-pot synthesis of 3, 4-dihydropyrimidin-2 (1 H)-
ones (DHPMs) using easily-accessible starting materials, namely, aldehyde, active …
ones (DHPMs) using easily-accessible starting materials, namely, aldehyde, active …
HSPA8/HSC70 chaperone protein: structure, function, and chemical targeting
F Stricher, C Macri, M Ruff, S Muller - Autophagy, 2013 - Taylor & Francis
HSPA8/HSC70 protein is a fascinating chaperone protein. It represents a constitutively
expressed, cognate protein of the HSP70 family, which is central in many cellular processes …
expressed, cognate protein of the HSP70 family, which is central in many cellular processes …
Features of protein–protein interactions that translate into potent inhibitors: topology, surface area and affinity
MC Smith, JE Gestwicki - Expert reviews in molecular medicine, 2012 - cambridge.org
Protein–protein interactions (PPIs) control the assembly of multi-protein complexes and,
thus, these contacts have enormous potential as drug targets. However, the field has …
thus, these contacts have enormous potential as drug targets. However, the field has …
J-domain protein chaperone circuits in proteostasis and disease
The J-domain proteins (JDP) form the largest protein family among cellular chaperones. In
cooperation with the Hsp70 chaperone system, these co-chaperones orchestrate a plethora …
cooperation with the Hsp70 chaperone system, these co-chaperones orchestrate a plethora …
Therapeutic targeting of BAG3: considering its complexity in cancer and heart disease
Bcl2-associated athanogene-3 (BAG3) is expressed ubiquitously in humans, but its levels
are highest in the heart, the skeletal muscle, and the central nervous system; it is also …
are highest in the heart, the skeletal muscle, and the central nervous system; it is also …
Structural and functional analysis of the Hsp70/Hsp40 chaperone system
Q Liu, C Liang, L Zhou - Protein Science, 2020 - Wiley Online Library
As one of the most abundant and highly conserved molecular chaperones, the 70‐kDa heat
shock proteins (Hsp70s) play a key role in maintaining cellular protein homeostasis …
shock proteins (Hsp70s) play a key role in maintaining cellular protein homeostasis …
Inhibition of HSP70: a challenging anti-cancer strategy
AR Goloudina, ON Demidov, C Garrido - Cancer letters, 2012 - Elsevier
HSP70 is a chaperone that accumulates in the cells after many different stresses promoting
cell survival in response to the adverse conditions. In contrast to normal cells, most cancer …
cell survival in response to the adverse conditions. In contrast to normal cells, most cancer …
The Hsp70-chaperone machines in bacteria
MP Mayer - Frontiers in Molecular Biosciences, 2021 - frontiersin.org
The ATP-dependent Hsp70s are evolutionary conserved molecular chaperones that
constitute central hubs of the cellular protein quality surveillance network. None of the other …
constitute central hubs of the cellular protein quality surveillance network. None of the other …
[HTML][HTML] The remarkable multivalency of the Hsp70 chaperones
ERP Zuiderweg, LE Hightower, JE Gestwicki - Cell Stress and Chaperones, 2017 - Elsevier
Hsp70 proteins are key to maintaining intracellular protein homeostasis. To carry out this
task, they employ a large number of cochaperones and adapter proteins. Here, we review …
task, they employ a large number of cochaperones and adapter proteins. Here, we review …
Hsp70 in cancer: A double agent in the battle between survival and death
MA Vostakolaei, L Hatami‐Baroogh… - Journal of cellular …, 2021 - Wiley Online Library
The heat shock protein (Hsps) superfamily, also known as molecular chaperones, are highly
conserved and present in all living organisms and play vital roles in protein fate. The …
conserved and present in all living organisms and play vital roles in protein fate. The …