The diabetes pandemic and associated infections: suggestions for clinical microbiology

A Toniolo, G Cassani, A Puggioni, A Rossi… - … and Research in …, 2019 - journals.lww.com
There are 425 million people with diabetes mellitus in the world. By 2045, this figure will
grow to over 600 million. Diabetes mellitus is classified among noncommunicable diseases …

Immunoendocrine dysregulation during gestational diabetes mellitus: The central role of the placenta

A Olmos-Ortiz, P Flores-Espinosa, L Díaz… - International Journal of …, 2021 - mdpi.com
Gestational Diabetes Mellitus (GDM) is a transitory metabolic condition caused by
dysregulation triggered by intolerance to carbohydrates, dysfunction of beta-pancreatic and …

Diabetes downregulates the antimicrobial peptide psoriasin and increases E. coli burden in the urinary bladder

S Mohanty, W Kamolvit, A Scheffschick… - Nature …, 2022 - nature.com
Diabetes is known to increase susceptibility to infections, partly due to impaired granulocyte
function and changes in the innate immunity. Here, we investigate the effect of diabetes, and …

Novel insight into the mechanisms of the bidirectional relationship between diabetes and periodontitis

F Barutta, S Bellini, M Durazzo, G Gruden - Biomedicines, 2022 - mdpi.com
Periodontitis and diabetes are two major global health problems despite their prevalence
being significantly underreported and underestimated. Both epidemiological and …

LL-37 transports immunoreactive cGAMP to activate STING signaling and enhance interferon-mediated host antiviral immunity

X Wei, L Zhang, Y Yang, Y Hou, Y Xu, Z Wang, H Su… - Cell Reports, 2022 - cell.com
Summary Cyclic 2′, 3′-GMP-AMP (cGAMP) binds to and activates stimulator of interferon
genes (STING), which then induces interferons to drive immune responses against tumors …

Host antimicrobial peptides: the promise of new treatment strategies against tuberculosis

J Arranz-Trullén, L Lu, D Pulido, S Bhakta… - Frontiers in …, 2017 - frontiersin.org
Tuberculosis (TB) continues to be a devastating infectious disease and remerges as a
global health emergency due to an alarming rise of antimicrobial resistance to its treatment …

Changes in Host Response to Mycobacterium tuberculosis Infection Associated With Type 2 Diabetes: Beyond Hyperglycemia

CA Segura-Cerda, W López-Romero… - Frontiers in cellular …, 2019 - frontiersin.org
Tuberculosis (TB) remains as the first cause of death among infectious diseases worldwide.
Global incidence of tuberculosis is in part coincident with incidence of type 2 diabetes (T2D) …

[HTML][HTML] Metformin promotes Mycobacterium tuberculosis killing and increases the production of human β-defensins in lung epithelial cells and macrophages

A Rodriguez-Carlos, C Valdez-Miramontes… - Microbes and …, 2020 - Elsevier
Diabetes has been associated with an increased risk of developing tuberculosis. The
reasons related to the increased susceptibility to develop TB in type 2 diabetes mellitus …

Circulating concentrations of cathelicidin anti-microbial peptide (camp) are increased during oral glucose tolerance test

A Höpfinger, T Karrasch, A Schäffler… - International Journal of …, 2023 - mdpi.com
Recent investigation has revealed the significant role of Cathelicidin antimicrobial peptide
(CAMP) in infection defense and innate immunity processes in adipose tissue. Meanwhile …

Predicting treatment failure, death and drug resistance using a computed risk score among newly diagnosed TB patients in Tamaulipas, Mexico

BE Abdelbary, M Garcia-Viveros… - Epidemiology & …, 2017 - cambridge.org
The purpose of this study was to develop a method for identifying newly diagnosed
tuberculosis (TB) patients at risk for TB adverse events in Tamaulipas, Mexico. Surveillance …