Type-specific dendrite morphology is a hallmark of the neuron and has important functional
implications in determining what signals a neuron receives and how these signals are …

The Drosophila larval neuromuscular system is relatively simple, containing only 32 motor
neurons in each abdominal hemisegment, and its neuromuscular junctions (NMJs) have …

Cellular granules lacking boundary membranes harbor RNAs and their associated proteins
and play diverse roles controlling the timing and location of protein synthesis. Formation of …

The molecular mechanisms that determine the size and complexity of the neuronal dendritic
tree are unclear. Here, we show that the phosphoinositide-3′ kinase (PI3K)–Akt …

Neuronal activity orchestrates the proper development of the neuronal circuitry by regulating
both transcriptional and post‐transcriptional gene expression programmes. How these …

Little is known about how the distinct architectures of dendrites and axons are established.
From a genetic screen, we isolated dendritic arbor reduction (dar) mutants with reduced …

The eukaryotic family of RNA-binding proteins termed PUF (Pumilio and FBF) is known for
its roles in cell division, differentiation and development. The best-characterized function of …

Local control of mRNA translation modulates neuronal development, synaptic plasticity, and
memory formation. A poorly understood aspect of this control is the role and composition of …

Model organisms such as the fruit fly Drosophila melanogaster can help to elucidate the
molecular basis of complex diseases such as cancer. Mutations in the Drosophila gene …

Puf proteins bind RNA sequence specifically and regulate translation and stability of target
mRNAs. A “code” for RNA recognition has been deduced from crystal structures of the Puf …