The most prevalent physiological effects of ANG II, the main product of the renin-angiotensin
system, are mediated by the AT1 receptor, a rhodopsin-like AGPCR. Numerous studies of …

To achieve a structural context for the analysis of G‐protein coupled receptor (GPCR)
oligomers, molecular modeling must be used to predict the corresponding interaction …

Ten years of experience with molecular class–specific information systems (MCSIS) such as
with the hand‐curated G protein–coupled receptor database (GPCRDB) or the …

The GPCRDB is a Molecular Class-Specific Information System (MCSIS) that collects,
combines, validates and disseminates large amounts of heterogeneous data on G protein …

The'omics era'(the era of genomics, proteomics, and so forth) is marked by a flood of data
that need to be interpreted to become useful information. Thanks to genome sequencing …

Motivation: The analysis of co-evolving residues has been exhaustively evaluated for the
prediction of intramolecular amino acid contacts in soluble proteins. Although a variety of …

Background G-Protein coupled receptors (GPCRs) comprise the largest group of eukaryotic
cell surface receptors with great pharmacological interest. A broad range of native ligands …

G-protein coupled receptors (GPCRs) are important drug targets for various diseases and of
major interest to pharmaceutical companies. The function of individual members of this …

The glycoprotein-hormone receptor information system (GRIS) presents a comprehensive
view on all available molecular data for the lutropin/choriogonadotropin receptor, follitropin …

Residues in the transmembrane region of G protein‐coupled receptors (GPCRs) are
important for ligand binding and activation, but the function of individual positions is poorly …