Sickle cell disease
Sickle cell disease (SCD) is a group of inherited disorders caused by mutations in HBB,
which encodes haemoglobin subunit β. The incidence is estimated to be between 300,000 …
which encodes haemoglobin subunit β. The incidence is estimated to be between 300,000 …
Sickle cell disease
RE Ware, M de Montalembert, L Tshilolo, MR Abboud - The Lancet, 2017 - thelancet.com
Sickle cell disease is a common and life-threatening haematological disorder that affects
millions of people worldwide. Abnormal sickle-shaped erythrocytes disrupt blood flow in …
millions of people worldwide. Abnormal sickle-shaped erythrocytes disrupt blood flow in …
Hydroxyurea for children with sickle cell anemia in sub-Saharan Africa
L Tshilolo, G Tomlinson, TN Williams… - … England Journal of …, 2019 - Mass Medical Soc
Background Hydroxyurea is an effective treatment for sickle cell anemia, but few studies
have been conducted in sub-Saharan Africa, where the burden is greatest. Coexisting …
have been conducted in sub-Saharan Africa, where the burden is greatest. Coexisting …
Hydroxyurea therapy for sickle cell anemia
PT McGann, RE Ware - Expert opinion on drug safety, 2015 - Taylor & Francis
Introduction: Sickle cell anemia (SCA) is a severe, inherited hemoglobin disorder affecting
100,000 persons in the US and millions worldwide. Hydroxyurea, a once daily oral …
100,000 persons in the US and millions worldwide. Hydroxyurea, a once daily oral …
Hydroxyurea dose escalation for sickle cell anemia in Sub-Saharan Africa
Background Hydroxyurea has proven safety, feasibility, and efficacy in children with sickle
cell anemia in sub-Saharan Africa, with studies showing a reduced incidence of vaso …
cell anemia in sub-Saharan Africa, with studies showing a reduced incidence of vaso …
A review of the relationship between the immune response, inflammation, oxidative stress, and the pathogenesis of sickle cell anaemia
Sickle cell anaemia (SCD) is a life-threatening haematological disorder which is
predominant in sub-Saharan Africa and is triggered by a genetic mutation of the β-chain …
predominant in sub-Saharan Africa and is triggered by a genetic mutation of the β-chain …
Sickle cell anemia in sub-Saharan Africa: advancing the clinical paradigm through partnerships and research
PT McGann, AG Hernandez… - Blood, The Journal of the …, 2017 - ashpublications.org
Sickle cell anemia (SCA) carries orphan disease designation in the United States, with;
2000 affected infants born annually and fewer than 100 000 persons living with this …
2000 affected infants born annually and fewer than 100 000 persons living with this …
Hydroxyurea treatment is associated with lower malaria incidence in children with sickle cell anemia in sub-Saharan Africa
Abstract Realizing Effectiveness Across Continents with Hydroxyurea (REACH,
NCT01966731) provides hydroxyurea at maximum tolerated dose (MTD) for children with …
NCT01966731) provides hydroxyurea at maximum tolerated dose (MTD) for children with …
Effective use of hydroxyurea for sickle cell anemia in low-resource countries
A Power-Hays, RE Ware - Current opinion in hematology, 2020 - journals.lww.com
Efforts to introduce hydroxyurea effectively into low-resource countries should urgently
address the lack of treatment guidelines, gaps in knowledge and clinical infrastructure, and …
address the lack of treatment guidelines, gaps in knowledge and clinical infrastructure, and …
Hydroxyurea with dose escalation for primary stroke risk reduction in children with sickle cell anaemia in Tanzania (SPHERE): an open-label, phase 2 trial
EE Ambrose, TS Latham, P Songoro… - The Lancet …, 2023 - thelancet.com
Summary Background Transcranial Doppler screening with chronic transfusions reduces
stroke risk in children with sickle cell anaemia but is not feasible in low-resource settings …
stroke risk in children with sickle cell anaemia but is not feasible in low-resource settings …