Prostaglandins (PGs) are the major lipid mediators in animals and which are biosynthesized
from arachidonic acid by the cyclooxygenases (COX-1 or COX-2) as the rate-limiting …

Abstract Prostaglandin E 2 (PGE 2) is one of the most typical lipid mediators produced from
arachidonic acid (AA) by cyclooxygenase (COX) as the rate-limiting enzyme, and acts on …

Endothelium‐dependent contractions contribute to endothelial dysfunction in various animal
models of aging, diabetes and cardiovascular diseases. In the spontaneously hypertensive …

The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the
blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in …

Prostacyclin (PGI2) is a member of the prostanoid group of eicosanoids that regulate
homeostasis, hemostasis, smooth muscle function and inflammation. Prostanoids are …

Background Infertility in mammalian females has been a challenge in reproductive
medicine. The causes of female infertility include anovulation, ovulated oocyte defects …

In response to various growth factors, hormones or cytokines, arachidonic acid can be
mobilized from phospholipids pools and converted to bioactive eicosanoids through …

15-Deoxy-Δ-12, 14-prostaglandin J2 (15d-PGJ2) is the most recently discovered
prostaglandin. This cyclopentanone, the dehydration end product of PGD2, differs from other …

Long regarded as proinflammatory molecules, prostaglandins (PGs) also have anti-
inflammatory effects. Both prostaglandin D2 (PGD2) and its dehydration end product 15 …

Many signaling pathways that contribute to tumorigenesis are also functional in pregnancy,
although they are dysregulated in the former and tightly regulated in the latter …