The concept of a matricellular protein was first proposed by Paul Bornstein in the mid-1990s
to account for the non-lethal phenotypes of mice with inactivated genes encoding …

Mechanical forces associated with blood flow play important roles in the acute control of
vascular tone, the regulation of arterial structure and remodeling, and the localization of …

Breast cancer progression features ECM stiffening due to excess deposition and
crosslinking of collagen, which dramatically influence tumor behaviour and fate. The …

The term matricellular proteins describes a family of structurally unrelated extracellular
macromolecules that, unlike structural matrix proteins, do not play a primary role in tissue …

The LDL receptor-related protein (originally called LRP, but now referred to as LRP1) is a
large endocytic receptor that is widely expressed in several tissues. LRP1 is a member of …

A secreted inhibitor of angiogenesis that is controlled by a tumor suppressor gene in
hamster cells has been found to be similar to a fragment of the platelet and matrix protein …

Regulation of the activation of latent TGF-β is essential for health as too much or too little
TGF-β activity can have serious, deleterious consequences. The processes that control …

Thrombospondin (TSP) forms specific complexes with transforming growth factor-beta (TGF-
beta) in the alpha granule releasate of platelets and these TSP-TGF-beta complexes inhibit …

Clustering of integrins into focal adhesions and focal complexes is regulated by the actin
cytoskeleton. In turn, actin dynamics are governed by Rho family GTPases. Integrin …

Thrombospondin (TSP) 2, and its close relative TSP1, are extracellular proteins whose
functions are complex, poorly understood, and controversial. In an attempt to determine the …