From somatic mutation to early detection: insights from molecular characterization of pancreatic cancer precursor lesions

CG Fischer, LD Wood - The Journal of pathology, 2018 - Wiley Online Library
Pancreatic cancer arises from noninvasive precursor lesions, including pancreatic
intraepithelial neoplasia (PanIN), intraductal papillary mucinous neoplasm (IPMN), and …

Humoral predictors of malignancy in IPMN: a review of the literature

EC Nista, T Schepis, M Candelli, L Giuli… - International Journal of …, 2021 - mdpi.com
Pancreatic cystic lesions are increasingly detected in cross-sectional imaging. Intraductal
papillary mucinous neoplasm (IPMN) is a mucin-producing subtype of the pancreatic cyst …

Molecular analysis of pancreatic cyst fluid for the management of intraductal papillary mucinous neoplasms

RC Turner, JT Melnychuk, W Chen, D Jones… - Diagnostics, 2022 - mdpi.com
Pancreatic cancer is one of the most lethal human cancers. Early detection and diagnosis of
precursor lesions for pancreatic malignancy is essential to improve the morbidity and …

The role of biomarkers in the early detection of pancreatic cancer

M Goggins - Familial Cancer, 2024 - Springer
Pancreatic surveillance can detect early-stage pancreatic cancer and achieve long-term
survival, but currently involves annual endoscopic ultrasound and MRI/MRCP, and is …

Intraductal pancreatic mucinous neoplasms: A tumor-biology based approach for risk stratification

V Nasca, M Chiaravalli, G Piro, A Esposito… - International Journal of …, 2020 - mdpi.com
Pancreatic ductal adenocarcinoma is one of the most lethal human cancers. Its precursor
lesions include pancreatic intra-epithelial neoplasia, mucinous cystic neoplasm, and …

Understanding, diagnosing, and treating pancreatic cancer from the perspective of telomeres and telomerase

S Shou, Y Li, J Chen, X Zhang, C Zhang, X Jiang… - Cancer Gene …, 2024 - nature.com
Telomerase is associated with cellular aging, and its presence limits cellular lifespan.
Telomerase by preventing telomere shortening can extend the number of cell divisions for …

Stratifying intraductal papillary mucinous neoplasms by cyst fluid analysis: present and future

S Hao, C Takahashi, RA Snyder, AA Parikh - International journal of …, 2020 - mdpi.com
A significant proportion of patients with intraductal papillary mucinous neoplasms (IPMNs)
undergo surgical resection in order to prevent or treat pancreatic cancer at the risk of …

RETRACTED: A subset of PARP inhibitors induces lethal telomere fusion in ALT-dependent tumor cells

J Mukherjee, A Pandita, C Kamalakar… - Science translational …, 2021 - science.org
About 10% of all tumors, including most lower-grade astrocytoma, rely on the alternative
lengthening of telomere (ALT) mechanism to resolve telomeric shortening and avoid …

Limitations and prospects in the management of IPMN: a retrospective, single-center observational study

S Peisl, O Burckhardt, B Egger - BMC surgery, 2023 - Springer
Background With increasing use and enhanced accuracy of cross-sectional imaging, the
diagnosis of intraductal papillary mucinous neoplasms (IPMNs) of the pancreas has …

Endoscopic Ultrasound-Guided Needle-Based Confocal Endomicroscopy as a Diagnostic Imaging Biomarker for Intraductal Papillary Mucinous Neoplasms

S Krishna, A Abdelbaki, PA Hart, JD Machicado - Cancers, 2024 - mdpi.com
Simple Summary Pancreatic cysts represent a category of lesions that arise in the pancreas
with the potential to transform into cancer. Intraductal papillary mucinous neoplasms …