Age-related vascular stiffening: causes and consequences
JC Kohn, MC Lampi, CA Reinhart-King - Frontiers in genetics, 2015 - frontiersin.org
Arterial stiffening occurs with age and is closely associated with the progression of
cardiovascular disease. Stiffening is most often studied at the level of the whole vessel …
cardiovascular disease. Stiffening is most often studied at the level of the whole vessel …
Vascular stiffening and endothelial dysfunction in atherosclerosis
A Hooglugt, O Klatt, S Huveneers - Current opinion in lipidology, 2022 - journals.lww.com
Future research that will define the endothelial contribution to stiffness-related
cardiovascular disease may provide new targets for intervention to restore endothelial …
cardiovascular disease may provide new targets for intervention to restore endothelial …
Replicating patient-specific severe aortic valve stenosis with functional 3D modeling
D Maragiannis, MS Jackson, SR Igo… - Circulation …, 2015 - Am Heart Assoc
Background—3D stereolithographic printing can be used to convert high-resolution
computed tomography images into life-size physical models. We sought to apply 3D printing …
computed tomography images into life-size physical models. We sought to apply 3D printing …
Vascular smooth muscle cell durotaxis depends on extracellular matrix composition
CD Hartman, BC Isenberg… - Proceedings of the …, 2016 - National Acad Sciences
Mechanical compliance has been demonstrated to be a key determinant of cell behavior,
directing processes such as spreading, migration, and differentiation. Durotaxis, directional …
directing processes such as spreading, migration, and differentiation. Durotaxis, directional …
Nanoindentation in materials research: Past, present, and future
The method we introduced in 1992 for measuring hardness and elastic modulus by
nanoindentation testing has been widely adopted and used in the characterization of …
nanoindentation testing has been widely adopted and used in the characterization of …
Biomechanical stress in coronary atherosclerosis: emerging insights from computational modelling
Coronary plaque rupture is the most common cause of vessel thrombosis and acute
coronary syndrome. The accurate early detection of plaques prone to rupture may allow …
coronary syndrome. The accurate early detection of plaques prone to rupture may allow …
Reduced substrate stiffness promotes M2-like macrophage activation and enhances peroxisome proliferator-activated receptor γ expression
The increased stiffness of the extracellular microenvironment observed in cancer and
atherosclerosis is thought to regulate the activation of tissue-resident immune cells …
atherosclerosis is thought to regulate the activation of tissue-resident immune cells …
Uniaxial tensile testing approaches for characterisation of atherosclerotic plaques
The pathological changes associated with the development of atherosclerotic plaques within
arterial vessels result in significant alterations to the mechanical properties of the diseased …
arterial vessels result in significant alterations to the mechanical properties of the diseased …
[HTML][HTML] Calcifications in atherosclerotic plaques and impact on plaque biomechanics
The catastrophic mechanical rupture of an atherosclerotic plaque is the underlying cause of
the majority of cardiovascular events. The infestation of vascular calcification in the plaques …
the majority of cardiovascular events. The infestation of vascular calcification in the plaques …
[HTML][HTML] Material properties of components in human carotid atherosclerotic plaques: a uniaxial extension study
Computational modelling to calculate the mechanical loading within atherosclerotic plaques
has been shown to be complementary to defining anatomical plaque features in determining …
has been shown to be complementary to defining anatomical plaque features in determining …