Historically, heterocyclic compounds including N-heterocycles and their derivatives are
valuable source for the identification of therapeutically active agents. Studies in the recent …

Four pyrazolopyrimidine series were prepared with a substitution at position-4 by Schiff
base, triazole, oxadiazole and pyrazole moieties (7a-f, 8a, b, 9a-f, 10a, b and 13a, b) …

Oxalic acid and proline based deep eutectic solvent (DES) has been identified as an
effective catalyst and environmentally benign reaction medium for one-pot synthesis of 13 …

Biocompatible and bio-based materials are an appealing resource for the pharmaceutical
industry. Poly (glycerol-adipate)(PGA) is a biocompatible and biodegradable polymer that …

Methyl-6-pyrazolyl-2-chloronicotinonitriles were synthesized by the reaction of 6-hydrazino-
4-methyl-2-chloronicotinonitriles with 1, 3-diketones. Upon treatment with hydrazine and …

A new series of 5-8 and 10 & 11 was prepared based on 4-(4-chlorophenyl)-2-mercapto-6-
oxo-1, 6-dihydropyrimidine-5-carbonitrile 4 and 4-(4-chlorophenyl)-2-hydrazinyl-6-oxo-1, 6 …

Pyrazolo [3, 4-d] pyrimidine is a bicyclic hetero organic nucleus that encompass a pyrazole
ring fusion with a pyrimidine ring. It was initially synthesized and evaluated as adenosine …

The aim of this study is to synthesize new benzenesulfonamide derivatives that possess
antibacterial activity using Bumetanide as a precursor of benzenesulfonamide. A novel …

Pyrazole is a five membered heteroaromatic ring with two nitrogen atoms is of immense
significance. Presence of this nucleus in the pharmacological agents of diverse therapeutic …

A literature search indicates that the presence of the pyrazole nucleus in different structures
allowed to prepare materials that were applied in technological areas, in medicine …