Refractory hypertension: a novel phenotype of antihypertensive treatment failure

T Dudenbostel, M Siddiqui, S Oparil, DA Calhoun - Hypertension, 2016 - Am Heart Assoc
Campinas, Brazil, Modolo et al8 compared 36 patients with refractory hypertension with 80
patients with resistant hypertension. Refractory hypertension was defined as uncontrolled …

Hypertension-linked pathophysiological alterations in the gut

MM Santisteban, Y Qi, J Zubcevic, S Kim… - Circulation …, 2017 - Am Heart Assoc
Rationale: Sympathetic nervous system control of inflammation plays a central role in
hypertension. The gut receives significant sympathetic innervation, is densely populated …

Resistance to antihypertensive drugs: is gut microbiota the missing link?

J Kyoung, RR Atluri, T Yang - Hypertension, 2022 - Am Heart Assoc
Microbiota colonization begins at birth and continuously reshapes throughout the course of
our lives, resulting in tremendous interindividual heterogeneity. Given that the gut …

Identification of a gut commensal that compromises the blood pressure-lowering effect of ester angiotensin-converting enzyme inhibitors

T Yang, X Mei, E Tackie-Yarboi, MT Akere… - …, 2022 - Am Heart Assoc
Background: Despite the availability of various classes of antihypertensive medications, a
large proportion of hypertensive individuals remain resistant to treatments. The reason for …

Prevalence and clinical characteristics of refractory hypertension

P Armario, DA Calhoun, A Oliveras… - Journal of the …, 2017 - Am Heart Assoc
Background We aimed to estimate the prevalence of refractory hypertension (RfH) and to
determine the clinical differences between these patients and resistant hypertensives (RH) …

Resistant Hypertension: Disease Burden and Emerging Treatment Options

JM Flack, MG Buhnerkempe, KT Moore - Current Hypertension Reports, 2024 - Springer
Abstract Purpose of Review To define resistant hypertension (RHT), review its
pathophysiology and disease burden, identify barriers to effective hypertension …

Resistant hypertension: mechanisms and treatment

AY Hwang, E Dietrich, CJ Pepine, SM Smith - Current Hypertension …, 2017 - Springer
Abstract Purpose of Review Emerging evidence suggests that multiple mechanisms may be
responsible for the development of treatment-resistant hypertension (TRH). This review aims …

Refractory hypertension and risks of adverse cardiovascular events and mortality in patients with resistant hypertension: a prospective cohort study

CRL Cardoso, GF Salles - Journal of the American Heart …, 2020 - Am Heart Assoc
Background The long‐term prognosis of refractory hypertension (RfHT), defined as failure to
control blood pressure (BP) levels despite an antihypertensive treatment with≥ 5 …

Selective deletion of the brain-specific isoform of renin causes neurogenic hypertension

K Shinohara, X Liu, DA Morgan, DR Davis… - …, 2016 - Am Heart Assoc
The renin–angiotensin system (RAS) in the brain is a critical determinant of blood pressure,
but the mechanisms regulating RAS activity in the brain remain unclear. Expression of brain …

Glycated hemoglobin correlates with arterial stiffness and endothelial dysfunction in patients with resistant hypertension and uncontrolled diabetes mellitus

B Moreno, AP de Faria, AMV Ritter… - The Journal of …, 2018 - Wiley Online Library
This study aimed to evaluate the effects of glycated hemoglobin (HbA1c) on flow‐mediated
dilation, intima‐media thickness, pulse wave velocity, and left ventricular mass index in …