Fibroblast‐like synoviocytes: key effector cells in rheumatoid arthritis

B Bartok, GS Firestein - Immunological reviews, 2010 - Wiley Online Library
Rheumatoid arthritis (RA) remains a significant unmet medical need despite significant
therapeutic advances. The pathogenesis of RA is complex and includes many cell types …

Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues

C Murdoch, A Giannoudis, CE Lewis - Blood, 2004 - ashpublications.org
The mechanisms responsible for recruiting monocytes from the bloodstream into solid
tumors are now well characterized. However, recent evidence has shown that these cells …

Synovial fibroblasts: key players in rheumatoid arthritis

LC Huber, O Distler, I Tarner, RE Gay, S Gay… - Rheumatology, 2006 - academic.oup.com
Rheumatoid arthritis (RA) is a chronic autoimmune-disease of unknown origin that primarily
affects the joints and ultimately leads to their destruction. The involvement of immune cells is …

CXCL1/macrophage inflammatory protein-2-induced angiogenesis in vivo is mediated by neutrophil-derived vascular endothelial growth factor-A

P Scapini, M Morini, C Tecchio, S Minghelli… - The Journal of …, 2004 - journals.aai.org
The angiogenic activity of CXC-ELR+ chemokines, including CXCL8/IL-8,
CXCL1/macrophage inflammatory protein-2 (MIP-2), and CXCL1/growth-related oncogene …

Rheumatoid arthritis: a practical guide to state-of-the-art imaging, image interpretation, and clinical implications

OJ Sommer, A Kladosek, V Weiler, H Czembirek… - Radiographics, 2005 - pubs.rsna.org
Rheumatoid arthritis (RA) is a chronic systemic disease of unknown origin that
predominantly involves synovial tissue. RA affects 0.5%–1.0% of the global population, with …

Identification of campesterol from Chrysanthemum coronarium L. and its antiangiogenic activities

JM Choi, EO Lee, HJ Lee, KH Kim, KS Ahn… - Phytotherapy …, 2007 - Wiley Online Library
Campesterol, a plant sterol in nature, is known to have cholesterol lowering and
anticarcinogenic effects. Since angiogenesis is essential for cancer, it was surmised that an …

Mechanisms of disease: angiogenesis in inflammatory diseases

Z Szekanecz, AE Koch - Nature clinical practice Rheumatology, 2007 - nature.com
Angiogenesis, the development of new vessels, is an important process in health and
disease. The perpetuation of neovascularization in inflammatory diseases, such as …

Human rheumatoid arthritis tissue production of IL-17A drives matrix and cartilage degradation: synergy with tumour necrosis factor-α, Oncostatin M and response to …

EM Moran, R Mullan, J McCormick, M Connolly… - Arthritis research & …, 2009 - Springer
Introduction The aim of this study was to examine IL-17A in patients, following anti-TNF-α
therapy and the effect of IL-17A on matrix turnover and cartilage degradation. Methods IL …

Potential of fibroblasts to regulate the formation of three-dimensional vessel-like structures from endothelial cells in vitro

LA Kunz-Schughart, JA Schroeder… - … of Physiology-Cell …, 2006 - journals.physiology.org
The development of vessel-like structures in vitro to mimic as well as to realize the possibility
of tissue-engineered small vascular networks presents a major challenge to cell biologists …

Flavonoids inhibit VEGF/bFGF‐induced angiogenesis in vitro by inhibiting the matrix‐degrading proteases

MH Kim - Journal of cellular biochemistry, 2003 - Wiley Online Library
Flavonoids have been proposed to act as chemopreventive agents in numerous
epidemiological studies and have been shown to inhibit angiogenesis and proliferation of …