Parvalbumin is a calcium-binding protein present in inhibitory interneurons that play an
essential role in regulating many physiological processes, such as intracellular signaling …

Epilepsy is based on abnormal neuronal activities that have historically been suggested to
arise from an excess of excitation and a defect of inhibition, or in other words from an …

Electrical neurostimulation is effective in the treatment of neurological disorders, but
associated recording artefacts generally limit its applications to open-loop stimuli. Real-time …

The type 2 K+/Cl− cotransporter (KCC2) allows neurons to maintain low intracellular levels
of Cl−, a prerequisite for efficient synaptic inhibition. Reductions in KCC2 activity are evident …

Abstract The K+-Cl− co-transporter KCC2 is a neuron-specific, Cl− extruder that uses K+
gradient for maintaining low intracellular [Cl−]. It is indeed well established that sustaining …

We review here the neuronal mechanisms that cause seizures in focal epileptic disorders
and, specifically, those involving limbic structures that are known to be implicated in human …

Epilepsy is a complex disease that requires various approaches for its study. This short
review discusses the contribution of theoretical and computational models. The review …

Under physiological conditions, neuronal network synchronization leads to different
oscillatory EEG patterns that are associated with specific behavioral and cognitive functions …

Since the discovery of inhibitory post-synaptic potentials (IPSPs) by Sir John Eccles in 1952,
and the identification of GABA (gamma-Aminobutyric acid) as the major inhibitory …

The biophysical mechanisms underlying epileptogenesis and the generation of seizures
remain to be better understood. Among many factors triggering epileptogenesis are …