The kisspeptin system in and beyond reproduction: exploring intricate pathways and potential links between endometriosis and polycystic ovary syndrome
Endometriosis and polycystic ovary syndrome (PCOS) are two common female reproductive
disorders with a significant impact on the health and quality of life of women affected. A …
disorders with a significant impact on the health and quality of life of women affected. A …
Aging-related ovarian failure and infertility: melatonin to the rescue
Aging has a major detrimental effect on the optimal function of the ovary with changes in this
organ preceding the age-related deterioration in other tissues, with the middle-aged …
organ preceding the age-related deterioration in other tissues, with the middle-aged …
Chromosome segregation in the oocyte: what goes wrong during aging
M Wasielak-Politowska, P Kordowitzki - International Journal of Molecular …, 2022 - mdpi.com
Human female fertility and reproductive lifespan decrease significantly with age, resulting in
an extended post-reproductive period. The central dogma in human female reproduction …
an extended post-reproductive period. The central dogma in human female reproduction …
Rejuvenation of aged oocyte through exposure to young follicular microenvironment
Reproductive aging is a major cause of fertility decline, attributed to decreased oocyte
quantity and developmental potential. A possible cause is aging of the surrounding follicular …
quantity and developmental potential. A possible cause is aging of the surrounding follicular …
Age-related changes in Folliculogenesis and potential modifiers to improve fertility outcomes-A narrative review
Reproductive aging is characterized by a decline in oocyte quantity and quality, which is
directly associated with a decline in reproductive potential, as well as poorer reproductive …
directly associated with a decline in reproductive potential, as well as poorer reproductive …
[HTML][HTML] Targeting organ-specific mitochondrial dysfunction to improve biological aging
CT Madreiter-Sokolowski, U Hiden, J Krstic… - Pharmacology & …, 2024 - Elsevier
In an aging society, unveiling new anti-aging strategies to prevent and combat aging-related
diseases is of utmost importance. Mitochondria are the primary ATP production sites and key …
diseases is of utmost importance. Mitochondria are the primary ATP production sites and key …
The role of cellular senescence in ovarian aging
JD Hense, JVV Isola, DN Garcia, LS Magalhães… - npj Aging, 2024 - nature.com
This review explores the relationship between ovarian aging and senescent cell
accumulation, as well as the efficacy of senolytics to improve reproductive longevity …
accumulation, as well as the efficacy of senolytics to improve reproductive longevity …
[HTML][HTML] miR-484 mediates oxidative stress-induced ovarian dysfunction and promotes granulosa cell apoptosis via SESN2 downregulation
X Wang, J Yang, H Li, H Mu, L Zeng, S Cai, P Su, H Li… - Redox Biology, 2023 - Elsevier
Ovarian dysfunction is a common cause of female infertility, which is associated with genetic,
autoimmune and environmental factors. Granulosa cells (GCs) constitute the largest cell …
autoimmune and environmental factors. Granulosa cells (GCs) constitute the largest cell …
Cumulus expansion is impaired with advanced reproductive age due to loss of matrix integrity and reduced hyaluronan
Reproductive aging is associated with ovulatory defects. Age‐related ovarian fibrosis
partially contributes to this phenotype as short‐term treatment with anti‐fibrotic compounds …
partially contributes to this phenotype as short‐term treatment with anti‐fibrotic compounds …
Granulosa cell metabolism at ovulation correlates with oocyte competence and is disrupted by obesity and aging
STUDY QUESTION Is oocyte developmental competence associated with changes in
granulosa cell (GC) metabolism? SUMMARY ANSWER GC metabolism is regulated by the …
granulosa cell (GC) metabolism? SUMMARY ANSWER GC metabolism is regulated by the …