Over the past 15 years, rapid progress has been made in developmental therapeutics,
especially regarding the use of matched targeted therapies against specific oncogenic …

Medical oncology is rapidly evolving with the implementation of personalized, targeted
therapies. Advances in molecular diagnostics and the biologic understanding of cancer …

Simple Summary Due to the increase of molecular biomarkers to be characterized to tailor
therapeutic strategies for non-squamous non-small cell lung carcinoma (NS-NSCLC), it is …

PURPOSE This review summarizes the published evidence on the clinical impact of using
next-generation sequencing (NGS) tests to guide management of patients with cancer in the …

Genomic-oriented oncology has improved tumor classification, treatment options, and
patient outcomes. However, genetic heterogeneity, tumor cell plasticity, and the ability of …

Background Germline mutations of breast cancer susceptibility gene BRCA1 and BRCA2
(gBRCA1/2) are associated with elevated risk of breast cancer in young women in Asia …

Multidisciplinary team from three universities based in the “Centro” Region of Portugal
developed diverse approaches as parts of a project dedicated to enhancing and expanding …

Precision medicine in breast cancer is a revolutionary approach that customizes diagnosis
and treatment based on individual and tumor characteristics, departing from the traditional …

Thyroid carcinomas exhibit various genetic alterations, including the RET and NTRK fusion
genes that are targets for molecular therapies. Thus, detecting fusion genes is crucial for …

Next-generation sequencing (NGS) can be used to detect tumor-specific genomic
alterations. This retrospective single-center study aims to assess the application of an …