Peroxiredoxin, senescence, and cancer

M Wu, C Deng, TH Lo, KY Chan, X Li, CM Wong - Cells, 2022 - mdpi.com
Peroxiredoxins are multifunctional enzymes that play a key role in protecting cells from
stresses and maintaining the homeostasis of many cellular processes. Peroxiredoxins were …

Overview of yeast environmental stress response pathways and the development of tolerant yeasts

NX Lin, Y Xu, XW Yu - Systems Microbiology and Biomanufacturing, 2022 - Springer
Yeast is widely used for industrial production of various types of products, such as ethanol
and enzymes. However, its fermentation efficiency is strongly reduced by harmful …

Hydrogen peroxide and amyotrophic lateral sclerosis: from biochemistry to pathophysiology

N Sanghai, GK Tranmer - Antioxidants, 2021 - mdpi.com
Free radicals are unstable chemical reactive species produced during Redox
dyshomeostasis (RDH) inside living cells and are implicated in the pathogenesis of various …

Peroxiredoxins in cancer and response to radiation therapies

TE Forshaw, R Holmila, KJ Nelson, JE Lewis, ML Kemp… - Antioxidants, 2019 - mdpi.com
Peroxiredoxins have a long-established cellular function as regulators of redox metabolism
by catalyzing the reduction of peroxides (eg, H2O2, lipid peroxides) with high catalytic …

ROS regulation in gliomas: implications for treatment strategies

YC Yang, Y Zhu, SJ Sun, CJ Zhao, Y Bai… - Frontiers in …, 2023 - frontiersin.org
Gliomas are one of the most common primary malignant tumours of the central nervous
system (CNS), of which glioblastomas (GBMs) are the most common and destructive type …

Loss of 2‐Cys‐Prx affects cellular ultrastructure, disturbs redox poise and impairs photosynthesis in cyanobacteria

P Kalwani, D Rath, A Ballal - Plant, Cell & Environment, 2022 - Wiley Online Library
In a striking similarity to plant chloroplasts, the cyanobacterium Anabaena displays very low
catalase activity, but expresses several peroxiredoxins (Prxs), including the typical 2‐Cys …

Augmented peroxisomal ROS buffering capacity renders oxidative and thermal stress cross-tolerance in yeast

NX Lin, RZ He, Y Xu, XW Yu - Microbial Cell Factories, 2021 - Springer
Background Thermotolerant yeast has outstanding potential in industrial applications.
Komagataella phaffii (Pichia pastoris) is a common cell factory for industrial production of …

The Peroxiredoxin Asp f3 Acts as Redox Sensor in Aspergillus fumigatus

JM Boysen, N Saeed, T Wolf, G Panagiotou, F Hillmann - Genes, 2021 - mdpi.com
The human pathogenic fungus Aspergillus fumigatus is readily eradicated by the innate
immunity of immunocompetent human hosts, but can cause severe infections, such as …

Aromatic residues at the dimer− dimer interface in the peroxiredoxin Tsa1 facilitate decamer formation and biological function

MA Loberg, JE Hurtig, AH Graff, KM Allan… - Chemical research in …, 2019 - ACS Publications
To prevent the accumulation of reactive oxygen species and limit associated damage to
biological macromolecules, cells express a variety of oxidant-detoxifying enzymes, including …

Comparative study of protective action of exogenous 2-Cys peroxiredoxins (Prx1 and Prx2) under renal ischemia-reperfusion injury

MG Sharapov, RG Goncharov, GI Filkov… - Antioxidants, 2020 - mdpi.com
The pathogenesis of ischemia-reperfusion (I/R) injuries is based on oxidative stress caused
by a sharp increase in the concentration of free radicals, reactive oxygen species (ROS) and …