Targeting isocitrate lyase for the treatment of latent tuberculosis
Highlights•Isocitrate lyase (ICL) is essential to growth and survival of Mycobacterium
tuberculosis (Mtb).•ICL is involved in Mtb glyoxylate and methylisocitrate cycles, and may …
tuberculosis (Mtb).•ICL is involved in Mtb glyoxylate and methylisocitrate cycles, and may …
Manipulation and Exploitation Of Host Immune System by Pathogenic Mycobacterium Tuberculosis for its Advantage
Mycobacterium tuberculosis (Mtb) can become a long-term infection by evading the host
immune response. Coevolution of Mtb with humans has resulted in its ability to hijack the …
immune response. Coevolution of Mtb with humans has resulted in its ability to hijack the …
Structure-based screening and molecular dynamics simulations offer novel natural compounds as potential inhibitors of Mycobacterium tuberculosis isocitrate lyase
Mycobacterium tuberculosis is the etiological agent of tuberculosis in humans and is
responsible for more than two million deaths annually. M. tuberculosis isocitrate lyase …
responsible for more than two million deaths annually. M. tuberculosis isocitrate lyase …
Distant Phe345 mutation compromises the stability and activity of Mycobacterium tuberculosis isocitrate lyase by modulating its structural flexibility
Isocitrate lyase (ICL), a potential anti-tubercular drug target, catalyzes the first step of the
glyoxylate shunt. In the present investigation, we studied the conformational flexibility of …
glyoxylate shunt. In the present investigation, we studied the conformational flexibility of …
Alterations in conformational topology and interaction dynamics caused by L418A mutation leads to activity loss of Mycobacterium tuberculosis isocitrate lyase
Mycobacterium tuberculosis isocitrate lyase (MtbICL) is a key enzyme of the glyoxylate cycle
that catalyzes the cleavage of isocitrate to succinate and glyoxylate and is a potential …
that catalyzes the cleavage of isocitrate to succinate and glyoxylate and is a potential …
Structural and energetic understanding of novel natural inhibitors of Mycobacterium tuberculosis malate synthase
Persistent infection by Mycobacterium tuberculosis requires the glyoxylate shunt. This is a
bypass to the tricarboxylic acid cycle in which isocitrate lyase (ICL) and malate synthase …
bypass to the tricarboxylic acid cycle in which isocitrate lyase (ICL) and malate synthase …
Activity loss by H46A mutation in Mycobacterium tuberculosis isocitrate lyase is due to decrease in structural plasticity and collective motions of the active site
Mycobacterium tuberculosis isocitrate lyase (MtbICL) is a crucial enzyme of the glyoxylate
cycle and is a validated anti-tuberculosis drug target. Structurally distant, non-active site …
cycle and is a validated anti-tuberculosis drug target. Structurally distant, non-active site …
Lysine succinylation of Mycobacterium tuberculosis isocitrate lyase (ICL) fine-tunes the microbial resistance to antibiotics
M Zhou, L Xie, Z Yang, J Zhou, J Xie - Journal of Biomolecular …, 2017 - Taylor & Francis
Lysine succinylation (Ksucc) is a newly identified protein posttranslational modification
(PTM), which may play an important role in cellular physiology. However, the role of lysine …
(PTM), which may play an important role in cellular physiology. However, the role of lysine …
Crystal Structure and Molecular Mechanism of Isocitrate Lyase from Chloroflexus aurantiacus
Chloroflexus aurantiacus is a green, nonsulfur bacterium that employs the 3-
hydroxypropionate cycle to grow, using carbon dioxide/bicarbonate as its primary carbon …
hydroxypropionate cycle to grow, using carbon dioxide/bicarbonate as its primary carbon …
Impact of protein dynamics on secondary structure prediction
AG de Brevern - Biochimie, 2020 - Elsevier
Protein 3D structures support their biological functions. As the number of protein structures is
negligible in regards to the number of available protein sequences, prediction …
negligible in regards to the number of available protein sequences, prediction …