Recombinant proteins are becoming increasingly important for industrial applications, where
Escherichia coli is the most widely used bacterial host for their production. However, the …

Formation of inclusion bodies in bacterial hosts poses a major challenge for large scale
recovery of bioactive proteins. The process of obtaining bioactive protein from inclusion …

Cell dormancy is a widespread mechanism used by bacteria to evade environmental
threats, including antibiotics. Here we monitored bacterial antibiotic tolerance and regrowth …

Protein misfolding and aggregation, a key contributor to the progression of numerous
neurodegenerative diseases, results in functional deficiencies and the creation of harmful …

Organisms must survive a variety of stressful conditions, including sudden temperature
increases that damage important cellular structures and interfere with essential functions. In …

Protein aggregation occurs as a consequence of perturbations in protein homeostasis that
can be triggered by environmental and cellular stresses. The accumulation of protein …

The composition of gut microbiota has been associated with host metabolic phenotypes, but
it is not known if gut bacteria may influence host appetite. Here we show that regular nutrient …

The quantitative study of the cell growth [1–5] has led to many fundamental insights in our
understanding of a wide range of subjects, from the cell cycle [6–9] to senescence [10]. Of …

The aggregation of misfolded proteins is associated with the perturbation of cellular function,
ageing and various human disorders. Mounting evidence suggests that protein aggregation …

Aberrantly processed or mutant proteins misfold and assemble into a variety of soluble
oligomers and insoluble aggregates, a process that is associated with an increasing number …