Targeting NR4A nuclear receptors to control stromal cell inflammation, metabolism, angiogenesis, and tumorigenesis

D Crean, EP Murphy - Frontiers in Cell and Developmental Biology, 2021 - frontiersin.org
The NR4A1–NR4A3 (Nur77, Nurr1, and Nor-1) subfamily of nuclear receptors is a group of
immediate early genes induced by a pleiotropy of stimuli including peptide hormones …

Nuclear receptor 4A (NR4A) family–orphans no more

S Safe, UH Jin, B Morpurgo, A Abudayyeh… - The Journal of steroid …, 2016 - Elsevier
The orphan nuclear receptors NR4A1, NR4A2 and NR4A3 are immediate early genes
induced by multiple stressors, and the NR4A receptors play an important role in maintaining …

[HTML][HTML] Global gene expression profile of periodontal ligament cells submitted to mechanical loading: A systematic review

A Spitz, IO Christovam, GA Marañón-Vásquez… - Archives of Oral …, 2020 - Elsevier
Objective To evaluate the evidence reporting gene expression array data of human in vitro
cultured periodontal ligament cells (PDLCs) submitted to static mechanical loading …

Recessive coding and regulatory mutations in FBLIM1 underlie the pathogenesis of chronic recurrent multifocal osteomyelitis (CRMO)

AJ Cox, BW Darbro, RM Laxer, G Velez, X Bing… - PloS one, 2017 - journals.plos.org
Chronic recurrent multifocal osteomyelitis (CRMO) is a rare, pediatric, autoinflammatory
disease characterized by bone pain due to sterile osteomyelitis, and is often accompanied …

NR4A1-3 nuclear receptor activity and immune cell dysregulation in rheumatic diseases

EP Murphy, D Crean - Frontiers in Medicine, 2022 - frontiersin.org
The development and progression of immune-mediated rheumatic disease (IMRD) involves
dysfunction of innate and adaptive immune cell populations leading to altered responses …

Psoriatic arthritis: recent progress in pathophysiology and drug development

DJ Veale - Arthritis research & therapy, 2013 - Springer
Psoriatic arthritis (PsA) is the second most common inflammatory arthropathy, after
rheumatoid arthritis diagnosis, in early arthritis clinics. Most patients have established …

Combination of H1 and H2 Histamine Receptor Antagonists: Current Knowledge and Perspectives of a Classic Treatment Strategy

E Kou, X Zhang, B Dong, B Wang, Y Zhu - Life, 2024 - mdpi.com
Histamine receptor antagonists, which can bind to specific histamine receptors on target
cells, exhibit substantial therapeutic efficacy in managing a variety of histamine-mediated …

[HTML][HTML] Mutations in osteoprotegerin account for the CCAL1 locus in calcium pyrophosphate deposition disease

CJ Williams, U Qazi, M Bernstein, A Charniak… - Osteoarthritis and …, 2018 - Elsevier
Objective Mutations on chromosomes 5p (CCAL2) and 8q (CCAL1) have been linked to
familial forms of calcium pyrophosphate deposition disease (CPDD). Mutations in the ANKH …

Effect of micro-osteoperforations on the gene expression profile of the periodontal ligament of orthodontically moved human teeth

A Spitz, D Adesse, M Gonzalez, R Pellegrino… - Clinical Oral …, 2022 - Springer
Objectives This study aimed to evaluate the effect of micro-osteoperforations (MOPs) on the
gene expression profile of the periodontal ligament (PDL) of orthodontically moved teeth …

Lentiviral small hairpin RNA knockdown of macrophage inflammatory protein-1γ ameliorates experimentally induced osteoarthritis in mice

PC Shen, CS Lu, AL Shiau, CH Lee, IM Jou… - Human Gene …, 2013 - liebertpub.com
Immune cells are involved in the pathogenesis of osteoarthritis (OA). CD4+ T cells were
activated during the onset of OA and induced macrophage inflammatory protein (MIP)-1γ …