Nitric oxide signalling in cardiovascular health and disease

C Farah, LYM Michel, JL Balligand - Nature Reviews Cardiology, 2018 - nature.com
Nitric oxide (NO) signalling has pleiotropic roles in biology and a crucial function in
cardiovascular homeostasis. Tremendous knowledge has been accumulated on the …

Molecular basis of cardioprotection: signal transduction in ischemic pre-, post-, and remote conditioning

G Heusch - Circulation research, 2015 - Am Heart Assoc
Reperfusion is mandatory to salvage ischemic myocardium from infarction, but reperfusion
per se contributes to injury and ultimate infarct size. Therefore, cardioprotection beyond that …

MicroRNAs in development and disease

D Sayed, M Abdellatif - Physiological reviews, 2011 - journals.physiology.org
MicroRNAs (miRNAs) are a class of posttranscriptional regulators that have recently
introduced an additional level of intricacy to our understanding of gene regulation. There are …

[HTML][HTML] The human HSP70 family of chaperones: where do we stand?

J Radons - Cell Stress and Chaperones, 2016 - Elsevier
The 70-kDa heat shock protein (HSP70) family of molecular chaperones represents one of
the most ubiquitous classes of chaperones and is highly conserved in all organisms …

Nuclear miRNA regulates the mitochondrial genome in the heart

S Das, M Ferlito, OA Kent, K Fox-Talbot… - Circulation …, 2012 - Am Heart Assoc
Rationale: Mitochondria are semiautonomous cellular organelles with their own genome,
which not only supply energy but also participate in cell death pathways. MicroRNAs …

MicroRNA-21 in cardiovascular disease

Y Cheng, C Zhang - Journal of cardiovascular translational research, 2010 - Springer
Abstract MicroRNA-21 (miR-21) is a highly expressed microRNA (miRNA) in cardiovascular
system. Recent studies have revealed that its expression is deregulated in heart and …

Heat shock proteins and heat shock factor 1 in carcinogenesis and tumor development: an update

DR Ciocca, AP Arrigo, SK Calderwood - Archives of toxicology, 2013 - Springer
Heat shock proteins (HSP) are a subset of the molecular chaperones, best known for their
rapid and abundant induction by stress. HSP genes are activated at the transcriptional level …

MicroRNA-21 is a downstream effector of AKT that mediates its antiapoptotic effects via suppression of Fas ligand

D Sayed, M He, C Hong, S Gao, S Rane, Z Yang… - Journal of Biological …, 2010 - ASBMB
MicroRNA-21 (miR-21) is highly up-regulated during hypertrophic and cancerous cell
growth. In contrast, we found that it declines in cardiac myocytes upon exposure to hypoxia …

Ischaemic preconditioning-regulated miR-21 protects heart against ischaemia/reperfusion injury via anti-apoptosis through its target PDCD4

Y Cheng, P Zhu, J Yang, X Liu, S Dong… - Cardiovascular …, 2010 - academic.oup.com
Aims The aims of the present study are to determine the miRNA expression signature in rat
hearts after ischaemic preconditioning (IP) and to identify an IP-regulated miRNA, miR-21, in …

The miR-15/107 group of microRNA genes: evolutionary biology, cellular functions, and roles in human diseases

JR Finnerty, WX Wang, SS Hébert, BR Wilfred… - Journal of molecular …, 2010 - Elsevier
The miR-15/107 group of microRNA (miRNA) gene is increasingly appreciated to serve key
functions in humans. These miRNAs regulate gene expression involved in cell division …