Phosphate, as a cellular energy currency, essentially drives most biochemical reactions
defining living organisms, and thus its homeostasis must be tightly regulated. Investigation …

Inositol pyrophosphates (IPPs) are present in organisms ranging from plants, slime moulds
and fungi to mammals. Distinct classes of kinases generate different forms of energetic …

Cryptococcus neoformans is the leading cause of death by fungal meningoencephalitis;
however, treatment options remain limited. Here we report the construction of 264 signature …

The free energy of nucleotide hydrolysis depends on phosphate concentration. Cells
regulate cytosolic phosphate levels by orchestrating phosphate acquisition and storage …

The inositol pyrophosphates 5-InsP7 (diphosphoinositol pentakisphosphate) and 1, 5-InsP8
(bis-diphosphoinositol tetrakisphosphate) are highly energetic cellular signals …

Cryptococcus neoformans is a common environmental saprophyte and human fungal
pathogen that primarily causes disease in immunocompromised individuals. Similar to many …

The inositol pyrophosphates (PP-IPs) are specialized members of the wider inositol
phosphate signaling family that possess functionally significant diphosphate groups. The PP …

Inositol hexakisphosphate kinase 3 (IP6K3) generates inositol pyrophosphates, which
regulate diverse cellular functions. However, little is known about its own physiological role …

Phosphatases, together with kinases and transcription factors, are key components in
cellular signalling networks. Here, we present a systematic functional analysis of the …

Phosphate is an essential macronutrient required for cell growth and division. Pho84 is the
major high-affinity cell-surface phosphate importer of Saccharomyces cerevisiae and a …