The purpose of this comprehensive review is to describe various aspects of crisis of opioid
use in the United States. The obstacles that must be surmounted are primarily inappropriate …

We review evidence of determinants contributing to increased opioid-related mortality in the
United States and Canada between 1990 and 2013. We identified 17 determinants of opioid …

Background The use of prescription drugs to improve cognitive functioning in normal
persons–“neuroenhancement”–has gained recent attention from bioethicists and …

Abstract Background The United States Food and Drug Administration's (FDA) Adverse
Event Reporting System (FAERS) consists of adverse event (AE) reports linked to approved …

BACKGROUND The US opioid epidemic has prompted dramatic changes in public attitudes
and regulations governing opioid prescribing. Little is known about the experiences of …

Opioid abuse has continued to increase at an alarming rate since the 1990 s. As
documented by different medical specialties, medical boards, advocacy groups, and the …

Introduction Post-marketing safety surveillance primarily relies on data from spontaneous
adverse event reports, medical literature, and observational databases. Limitations of these …

Firearm injury is a public health crisis in the United States. Selective media coverage may
contribute to incomplete public understanding of firearm injury. To better understand how …

Background Prescription opioid analgesic (POA) utilization has steeply increased globally,
yet is far higher in established market economies than elsewhere. Canada features the …

Context: The opioid epidemic has been well-documented in the general population, but the
literature pertaining to opioid use and misuse in the athletic population remains limited …