Significance: The primary role of platelets is to generate a thrombus by platelet activation.
Platelet activation relies on calcium mobilization from the endoplasmic reticulum (ER). ER …

The gray platelet syndrome (GPS) is a rare platelet disorder, characterized by impaired
alpha-granule biogenesis in megakaryocytes and platelets due to NBEAL2 mutations …

Loss of NBEAL2 function leads to grey platelet syndrome (GPS), a bleeding disorder
characterized by macro-thrombocytopenia and α-granule-deficient platelets. A proportion of …

Gray platelet syndrome (GPS) is an autosomal recessive bleeding disorder characterized by
a lack of α-granules in platelets and progressive myelofibrosis. Rare loss-of-function variants …

Megakaryocytes (MKs) produce platelets, and similar to other hematopoietic progenitors,
they are involved in homeostatic aspects of their bone marrow niche. MKs release and …

We recently achieved the first-in-human transfusion of induced pluripotent stem cell-derived
platelets (iPSC-PLTs) as an alternative to standard transfusions, which are dependent on …

Many roles of human platelets in health and disease are linked to their ability to transport
and secrete a variety of small molecules and proteins carried in dense (δ-) and α-granules …

In addition to being biological barriers where the internalization or release of biomolecules
is decided, cell membranes are contact structures between the interior and exterior of the …

This review is focused on genetic regulators of bleeding and thrombosis with a focus on next‐
generation sequencing (NGS) technologies for diagnosis and research of patients with …

Background Platelets coordinate blood coagulation at sites of vascular injury and play
fundamental roles in a wide variety of (patho) physiological processes. Key to many platelet …